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CD28 — IL5

Text-mined interactions from Literome

Umland et al., Am J Respir Cell Mol Biol 1999 (Hypersensitivity...) : Of the cytokine mRNAs examined in the lungs of CSA pretreated, antigen challenged mice, IL-5 mRNA levels were the least reduced, paralleling the resistance of IL-5 to CSA observed in vitro and suggesting a role for CD28 in the in vivo induction of IL-5
Staples et al., Biochem Biophys Res Commun 2000 : By contrast, IL-10 totally inhibited CD3 + CD28 induced IL-5 release and inhibited mRNA by 50-60 %
Verbon et al., Antimicrob Agents Chemother 2000 : In all six volunteers ingestion of thalidomide was associated with enhanced SEB- and anti-CD3/CD28 induced production of the Th1 cytokine gamma interferon ( P < 0.05 ) and a decrease in the level of anti-CD3/CD28 induced interleukin-5 (IL-5) production ( P < 0.05 )
Okkenhaug et al., Nat Immunol 2001 : Nonetheless, this mutated form of CD28 still prevents the induction of anergy and promotes T cell proliferation, interleukin 2 secretion and B cell help
Lordan et al., J Allergy Clin Immunol 2001 (Asthma) : These data suggest that IL-5 production in the airways of subjects with moderately severe asthma is largely independent of CD28 mediated costimulation
Marin et al., Exp Hematol 2007 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Moreover, the presence of 4-1BB or CD28 in the receptor increased the production of interleukin (IL)-2, tumor necrosis factor (TNF)-alpha, TNF-beta, IL-5 , IL-6, and IL-8 elicited by coculture with ALL cells
Koch et al., Clin Immunol 2007 (Asthma) : There was an increased anti-CD3/anti-CD28 induced IL-5 expression in T cells of asthmatics compared with normals ( p < 0.01 )
Abreu et al., Arthritis Res Ther 2010 (Arthritis, Experimental...) : Ex vivo, Rac1 inhibitory peptide suppressed T-cell receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Smeets et al., BMC immunology 2012 : Translation towards a primary, whole blood setting and purified human CD4+ T cells revealed that PMA/CD3 stimulation induced a more pronounced Th1 specific, Lck and PKC? dependent IFN? production, whereas PMA/CD28 induced Th2 specific IL-5 and IL-13 production, independent of Lck activation
Dumont et al., J Immunol 1998 : PD98059 inhibited TNF-alpha, IL-3, granulocyte-macrophage (GM)-CSF, IFN-gamma, and to a lesser extent IL-6 and IL-10 production but enhanced IL-4, IL-5 , and IL-13 production induced by CD3/PMA or CD3/CD28