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LYN — MYLIP

Text-mined interactions from Literome

Zimmerman et al., Mol Pharmacol 2010 (Leukemia, Myeloid) : Lyn kinase dependent regulation of miR181 and myeloid cell leukemia-1 expression : implications for drug resistance in myelogenous leukemia ... A similar Lyn dependent regulation of miR181b and miR181d was observed in imatinib-resistant K562 CML cells ... In summary, our results suggest that Lyn dependent regulation of miR181 is a novel mechanism of regulating Mcl-1 expression and cell survival
Liu et al., Arthritis Rheum 2013 (Lupus Erythematosus, Systemic) : In B cell lines, miR-30a, but not miR-30b , miR-30c, miR-30d, or miR-30e, could specifically bind the 3'-UTR of Lyn, and overexpression of miR-30a inhibited the levels of Lyn ... These results reveal that elevated expression of miR-30a is responsible for the reduction in levels of Lyn in B cells from patients with SLE, suggesting that miR-30a plays an important role in B cell hyperactivity