◀ Back to IL6
IKBKG — IL6
Text-mined interactions from Literome
Li et al., J Exp Med 1999
:
Accordingly, IKKbeta-deficient cells are defective in activation of
IKK and NF-kappaB in
response to either tumor necrosis factor alpha or
interleukin 1
Zhang et al., EMBO Rep 2005
:
Using IKK(beta)-deficient bone-marrow derived macrophages and mouse embryo fibroblasts ( MEFs ), we show that IKK(beta) is essential for
IKK and NF-(kappa)B activation as well as efficient
IL-6 induction
Catley et al., Mol Pharmacol 2006
(Pulmonary Disease, Chronic Obstructive) :
As observed above, ICAM-1,
IL-6 , IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was
reduced by the
IKK inhibitors
Lamothe et al., J Biol Chem 2007
:
Reconstituting TRAF6-deficent cells with various TRAF6 mutants, we clearly demonstrate the requirement for the TRAF6 RING domain and site-specific auto-ubiquitination of TRAF6 to activate
IKK in
response to
interleukin-1
Grund et al., Mol Pharmacol 2008
(Endometriosis...) :
Interestingly, MEK, p38, and
IKK inhibitors
block TNF-alpha induced IL-8,
IL-6 , and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
O'Connell et al., J Biol Chem 1998
:
Recently, we have reported that the tumor necrosis factor and
interleukin 1 signaling pathways
activate two kinases,
IKK1 and IKK2