◀ Back to IL6
IL6 — TNFSF11
Text-mined interactions from Literome
Josien et al., J Immunol 1999
:
In DCs,
TRANCE induces the expression of proinflammatory cytokines (
IL-6 , IL-1 ) and T cell growth and differentiation factors ( IL-12, IL-15 ) in addition to enhancing DC survival
O'Brien et al., J Biol Chem 1999
:
Moreover, dn-STAT3 blocked the ability of either
IL-6 + soluble IL-6 receptor or oncostatin M to
induce RANKL
Hofbauer et al., Bone 1999
:
By northern analysis, IL-1beta ( 5 nmol/L ) and TNF-alpha ( 9 nmol/L ) increased OPG-L mRNA steady-state levels by up to two- to three-fold in normal marrow stromal cells ( MS ), an immortalized marrow stromal cell line ( hMS ), and the osteosarcoma cell line, MG-63, whereas
IL-6 ( 2 nmol/L, with or without its soluble receptor )
had no effect on
OPG-L mRNA levels in any of these cells
Giuliani et al., Blood 2002
(Multiple Myeloma...) :
In addition, either
anti-interleukin 6 ( anti-IL-6 ) or anti-IL-7 antibody
inhibited HMCL induced
RANKL overexpression
Sieghart et al., Wien Med Wochenschr 2004
(Fractures, Spontaneous...) :
increased sensitivity of osteoclast-precursors to 1,25 ( OH ) 2Vitamin D3 and
RANKL ,
mediated by
IL6 have been described as a possible mechanism
Giuliani et al., Haematologica 2004
(Multiple Myeloma) :
Consistently,
RANKL did not have a direct effect on myeloma cell survival, but RANKL treatment
induced a significant increase of
interleukin (IL)-6 and IL-11 secretion by both BMSC and endothelial cells
O'Brien et al., Am J Physiol Endocrinol Metab 2005
(Bone Resorption...) :
IL-6 is not
required for parathyroid hormone stimulation of
RANKL expression, osteoclast formation, and bone loss in mice
Shaarawy et al., J Soc Gynecol Investig 2005
(Bone Resorption...) :
The increased osteoclastic activity in preeclampsia may be attributed to increased
RANKL induced by increased
interleukin-6 (IL-6) , tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor beta2 ( TGF-beta2 ) production
Park et al., Exp Mol Med 2005
:
In addition,
RANKL increased the expression of TNFalpha, MCP-1, and
IL-6 but not of IL-10, IL-12, IFN-gamma, and iNOS
Lamothe et al., J Biol Chem 2008
:
Additionally, expression of TRAF6 lacking ZF2-4 in TRAF6-deficient monocytes rescues
RANKL mediated osteoclast differentiation and LPS stimulated
interleukin-6 production
Hashizume et al., Rheumatology (Oxford) 2008
(Arthritis, Rheumatoid) :
IL-6 trans signalling directly
induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17 ...
RANKL expression was
induced by
IL-6/sIL-6R ( but not IL-6 alone ) and by IL-1beta ... On the other hand, TNF-alpha and IL-17 did not
induce RANKL expression, although TNF-alpha, IL-17 or IL-1beta stimulated cell growth and
IL-6 production ... PAR completely inhibited
IL-6/sIL-6R induced
RANKL expression, but PD did not ...
IL-6/sIL-6R directly induced RANKL expression in RA-FLS and it is
essential for
RANKL induction by TNF-alpha and IL-17 ... Moreover,
RANKL induction by
IL-6/sIL-6R is mediated by the janus kinase/STAT signalling pathway
Suzuki et al., Clin Exp Immunol 2011
:
IL-6+sIL-6R treatment significantly
induced RANKL production in SW982 cells, and anti-RANKL antibody inhibited IL-6+sIL-6R induced osteoclastogenesis
Noh et al., Life Sci 2011
(Bone Resorption) :
While the
RANKL stimulated induction of IL-1ß and
IL-6 was not affected, TNF-a induction was reduced by BayK 8644 treatment
Kaneko et al., J Clin Endocrinol Metab 2012
(Autoimmune Diseases) :
Up-regulation of
RANKL and OPG mRNA by
IL-6 was suppressed by dexamethasone
Zheng et al., Biochem Pharmacol 2013
(Bone Resorption) :
Coumermycin A1 also abrogated
RANKL induced expression of
interleukin-1ß , tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments