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CXCL12 — PLAU
Text-mined interactions from Literome
Hsu et al., J Cell Physiol 2012
(Carcinoma, Hepatocellular...) :
SK-Hep-1 cells stimulation with
uPA induced increases in the expression and secretion of
SDF-1 ... By using specific inhibitors and small interfering RNA, we have demonstrated that the activation of extracellular signal related kinase ( ERK ) and c-Jun-NH ( 2 ) -terminal kinase ( JNK ) pathways are critical for
uPA induced
SDF-1 expression ... Inhibition of Sp1 and AP-1 activations by specific siRNAs blocked the
uPA induced
SDF-1 promoter activity and expression ... The
effect of
uPA on SK-Hep-1 signaling and
SDF-1 expression is mediated by uPAR
Dar et al., Leukemia 2011
:
Additionally, ROS inhibition reduced AMD3100 induced
SDF-1 release,
activation of circulating
uPA and mobilization of progenitor cells
Huang et al., J Cell Physiol 2012
(Colorectal Neoplasms...) :
We found that
SDF-1 stimulation
led to an increase in the expression and secretion of
uPA in these cells ... Experiments involving specific inhibitors and small interfering RNA demonstrated that the activation of p38 mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K)/Akt pathways are critical for
SDF-1 induced
uPA expression ... Inhibition of Sp1 and AP-1 activation blocked the
SDF-1 induced expression and activity of the
uPA promoter ... The
effect of
SDF-1 on DLD-1 signaling and
uPA expression was mediated by the CXCR4/ß1 integrin axis