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CA2 — SNAP25
Text-mined interactions from Literome
GarcĂa-Palomero et al., J Neurochem 2000
:
These findings, together with the fact that nicotinic receptor activation or
Ca2+ release from internal stores also
enhanced SNAP-25 protein expression, suggest that an increment of cytosolic Ca2+ concentration ([Ca2+]), rather than its source or Ca2+ entry pathway, is the critical signal to induce the protein expression
Nakata et al., Cell Struct Funct 1999
(Diabetes Mellitus, Type 1...) :
SNAP at 200 microM
increased cytosolic
Ca2+ concentration ([Ca2+]i) and induced apoptosis
Chieregatti et al., Traffic 2002
:
These results show that Ca2+ modulates dynamic docking of granules to the plasma membrane and that this process is due to a
Ca2+ dependent interaction between
SNAP-25 and Synaptotagmin 1
Zhang et al., Neuron 2002
(Calcium Signaling...) :
Synaptotagmin is a proposed Ca2+ sensor on the vesicle for regulated exocytosis and exhibits
Ca2+ dependent binding to phospholipids, syntaxin, and
SNAP-25 in vitro, but the mechanism by which Ca2+ triggers membrane fusion is uncertain ... Previous studies suggested that
SNAP-25 plays a role in the
Ca2+ regulation of secretion ... These results indicate that the
Ca2+ dependent interaction of synaptotagmin with
SNAP-25 is essential for the Ca2+ dependent triggering of membrane fusion
Chen et al., J Mol Biol 2005
:
Indeed, overexpression of
SNAP-25 bearing mutations in two putative Ca2+ ligands ( E170A/Q177A )
causes a decrease in the
Ca2+-cooperativity of exocytosis in chromaffin cells
Ando et al., J Neurochem 2005
:
Calpain inhibitors abolished the
Ca2+ dependent cleavage of
SNAP-25 and markedly facilitated Ca2+ dependent glutamate ( Glu ) release from cerebellar granule cells
Shen et al., Brain Res 2006
(Calcium Signaling) :
S-nitroso-N-acetylpenicillamine (SNAP) , a NO donor,
enhanced the ATP induced increase of the intracellular
Ca2+ concentrations ([Ca2+]i) , while L-NAME inhibited it
Lopez et al., FASEB J 2007
:
Previous studies indicate that the process requires Rab3 dependent tethering of membranes,
SNARE complex assembly, and
Ca2+ mediated
activation of synaptotagmin
Lermioglu et al., Biochem J 1991
:
Increasing cell density was significantly correlated with the decrease in cytosolic free
Ca2+ induced by ANP ( 99-126 ) or
SNAP
Ramakrishnan et al., J Biol Chem 2009
(Deafness) :
The native otoferlin C2F domain bound syntaxin 1A and
SNAP-25 in a
Ca2+ dependent manner ( with optimal 61 microm free Ca2+ required for binding )
Sokolovski et al., Mol Plant 2008
(Ion Channel Gating) :
Here, we report one mode of action for the
SNARE mediated directly through alterations in Ca2+ channel gating and its consequent effects on cytosolic-free [ Ca2+ ] ( [
Ca2+ ] i ) elevation
Kannan et al., Am J Physiol 1997
:
SNAP inhibited ACh induced SR
Ca2+ release at both 0 and 2.5 mM extracellular Ca2+ ... Degraded
SNAP had no effect on ACh induced SR
Ca2+ release ...
SNAP also
inhibited caffeine induced SR
Ca2+ release ... These results suggest that, in porcine TSM cells,
SNAP reduces the intracellular
Ca2+ response to ACh and caffeine by inhibiting SR Ca2+ release through both IP3 and RyR, but not by inhibiting influx or repletion of the SR Ca2+ stores