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GRAP2 — PAK1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
GRAP2
→
PAK1
(indirect_complex)
Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Lu et al., Oncogene 1999
-
Reactome Reaction:
GRAP2
→
PAK1
(reaction)
Chong et al., J Biol Chem 2001, Parrini et al., Mol Cell 2002, Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Lu et al., Oncogene 1999
Text-mined interactions from Literome
Lee et al., J Biol Chem 2001
:
This betaPix induced p38 activation was blocked by coexpression of dominant negative Cdc42/Rac or kinase-inactive PAK, indicating that the effect of betaPix on
p38 is exerted through the Cdc42/Rac-PAK pathway and
requires PAK kinase activity
Chan et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
Overexpression of a PAK inhibitory peptide or dominant negative Cdc42 revealed that
p38 activation was
dependent on
PAK and Cdc42 activities
Gamell et al., PloS one 2011
:
These signaling effects on
p38/MK2/Hsp25 do not
require the activity of either Cdc42 or
PAK , whereas p38/MK2 activities do not significantly modify the BMP-2 dependent activation of LIMK1, measured by either kinase activity or with an antibody raised against phospho-threonine 508 at its activation loop
Shifrin et al., Biochem J 2012
(Mechanotransduction, Cellular) :
Depletion of
Pak1 ( p21 activated kinase 1 ), a downstream effector of Rac,
prevented force induced
p38 activation and apoptosis