Gene interactions and pathways from curated databases and text-mining

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CASP3 — MEFV

Text-mined interactions from Literome

Tang et al., J Neurosci 2005 : Destabilization of MEF2 is caused by an increase in caspase dependent cleavage of MEF2
Chae et al., Proc Natl Acad Sci U S A 2006 (Familial Mediterranean Fever) : Pyrin , the protein mutated in FMF, regulates caspase-1 activation and consequently IL-1beta production through cognate interaction of its N-terminal PYRIN motif with the ASC adaptor protein
Roldan et al., Joint Bone Spine 2008 (Familial Mediterranean Fever) : Pyrin , the protein mutated in FMF, regulates caspase-1 activation and consequently IL-1beta production
Chae et al., Br J Haematol 2009 (Familial Mediterranean Fever) : Pyrin regulates caspase-1 activation and consequently interleukin-1beta production through the interactions of its N-terminal PYRIN domain and C-terminal B30.2 domain with an adaptor protein, apoptosis associated speck-like protein with a caspase-recruitment domain (ASC) and caspase-1 respectively