Randazzo et al., J Biol Chem 1994
:
PIP2 alone stimulated ARF GAP activity up to 30-fold with a half-maximal effect at 100-300 microM but had no effect on the GTPase rate of ARF alone
Kahn et al., J Lipid Mediat Cell Signal 1996
:
The previously described requirements for PIP2 in the ARF stimulated phospholipase D ( PLD ) activity and ARF GTPase activating protein ( ARF GAP ) assays provide the basis for a model in which PIP2 acts as a cofactor in one or more ARF pathways