◀ Back to TGFB1

MAP3K7 — TGFB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP3K7 → TGFB1 (increases, TGFB1 Activity) Channavajhala et al., J Biol Chem 2003*
  Evidence: Cot-induced interleukin-8 production in HeLa cells is almost completely inhibited by the concurrent expression of hKSR-2, whereas transforming growth factor beta-activated kinase 1 (TAK1)/TAK1-binding protein 1 (TAB1)-induced interleukin-8 production is not affected by hKSR-2 co-expression.
• OpenBEL Selventa BEL large corpus: MAP3K7 → TGFB1 (increases, TGFB1 Activity) Dowdy et al., J Biol Chem 2003*
  Evidence: Our data showing Smad7 activation by TAK1 and ER81 suggests an additional negative feedback loop, as TGF- is known to induce TAK1 activity (37).

Text-mined interactions from Literome

Zhang et al., Nat Med 2000 (Cardiac Output, Low...) : The transforming-growth-factor-beta activated kinase TAK1 is a member of the mitogen activated protein kinase kinase kinase family, which couples extracellular stimuli to gene transcription
Marone et al., Leukemia 2002 (Leukemia, Erythroblastic, Acute...) : In other systems TGF-beta1 has been shown to activate a TGF-beta activated kinase 1 (TAK1) , which in turn, activates p38
Lim et al., J Mol Cell Cardiol 2005 (Cardiomegaly) : The PKC inhibitors, GO6976 and GF109203X, completely blocked TGF-beta1 induced TAK1 kinase activity and subsequent downstream signaling pathways including ATF-2 phosphorylation, leading to suppression of ATF-2 transcriptional activity
Kim et al., American journal of physiology. Renal physiology 2007 : Rapid activation of endogenous TAK1 activity by TGF-beta(1) was observed in mouse mesangial cells
Safina et al., Oncogene 2008 (Lung Neoplasms...) : TAK1 is required for TGF-beta 1-mediated regulation of matrix metalloproteinase-9 and metastasis
Kim et al., J Biol Chem 2008 : Protein phosphatase 2A is a negative regulator of transforming growth factor-beta1 induced TAK1 activation in mesangial cells ... Here we demonstrate that protein phosphatase 2A (PP2A) plays a pivotal role as a negative regulator of TAK1 activation in response to TGF-beta1 in mesangial cells ... TGF-beta1 stimulation rapidly activates TAK1 in a biphasic manner, indicating that TGF-beta1 induced TAK1 activation is tightly regulated ... The association of PP2A ( C ) with TAK1 is enhanced in response to TGF-beta1 stimulation and closely parallels TGF-beta1 induced TAK1 activity ... The association of PP2A ( C ) with TAK1 is enhanced in response to TGF-beta1 stimulation and closely parallels TGF-beta1 induced TAK1 activity ... Attenuation of PP2A activity by OA treatment or targeted knockdown of PP2A ( C ) with small interfering RNA enhances TGF-beta1 induced phosphorylation of TAK1 at Thr-187 and MKK3 ( MAPK kinase 3 ) ... Endogenous TAK1 co-precipitates with PP2A ( C ) but not PP6 ( C ), another OA-sensitive protein phosphatase, and knockdown of PP6 ( C ) by small interfering RNA does not affect TGF-beta1 induced phosphorylation of TAK1 at Thr-187 and MKK3 ... Taken together, our data indicate that PP2A functions as a negative regulator in TGF-beta1 induced TAK1 activation
Kim et al., J Biol Chem 2009 : Here, we propose a mechanism whereby TAK1 is activated by TGF-beta1 in primary mouse mesangial cells ... TGF-beta1 stimulation causes rapid dissociation from the receptor and induces TAK1 phosphorylation ... Both TbetaRI mediated TAK1 phosphorylation and TGF-beta1 induced TAK1 phosphorylation do not require kinase activity of TbetaRI ... TAB1 does not interact with TGF-beta receptors, but TAB1 is indispensable for TGF-beta1 induced TAK1 activation ... We also show that TRAF6 and TAB2 are required for the interaction of TAK1 with TbetaRI and TGF-beta1 induced TAK1 activation in mouse mesangial cells
Venables et al., Mol Biol Evol 2012 : Of the 40 in the starting set, the most conserved alternative splicing event was in the transforming growth factor ( TGF ) beta activated kinase Tak1 ( MAP3K7 ) as this was also muscle specific in urochordates and in Ambulacraria, the most ancient deuterostome clade
Liu et al., Zhongguo Zhong Yao Za Zhi 2011 : Fushenkeli could inhibits TAK1 expression induced by TGF-beta1 in the proliferation of HK-2 cell