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CD4 — IL15

Text-mined interactions from Literome

Lin et al., Pediatr Allergy Immunol 2001 : Interleukin-15 enhances CD4 ( + ) CD45RA ( + ) expression on umbilical cord blood mononuclear cells
Villinger et al., Vaccine 2004 : IL-15 also significantly enhanced early and late TT specific CD4 responses
Picker et al., J Clin Invest 2006 (HIV Infections...) : IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates
Pepe et al., Curr Pharm Des 2006 : This Th1 polarizing activity is mediated by interleukin-12 released by infected CDs in the presence of CD4 ( + ) cells
Ariga et al., Immunology 2007 : Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive CD4 ( + ) T cells induces transient T-bet expression, interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Fan et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 (Autoimmune Diseases) : IL-23, IL-2 and IL-15 can directly induce CD4 ( + ) T cells to produce IL-17 and IFN-gamma
Patterson et al., Virology 2008 (HIV Infections) : Both IL-2 and IL-15 increased cytomegalovirus induced CD4+ and CD8+ T-cell proliferation and the synthesis of Th1 and pro-inflammatory cytokines and chemokines
Zhu et al., Gastroenterology 2010 (Eosinophilia...) : IL-15 activated STAT5 and CD4 ( + ) T cells to produce cytokines that act on eosinophils ... IL-15 activates CD4 ( + ) T cells to produce cytokines that act on eosinophils
Zhang et al., J Leukoc Biol 2010 : CpG treated, CD4-8- DCOVA secreting IL-6/IL-15 induced IFN-gamma/IL-17-secreting/T-bet- and ROR-gammat expressing CD4+ Th1/Th17, whereas LPS treated CD4-8- DCOVA stimulated IFN-gamma-secreting/T-bet expressing CD4+ Th1 responses
Tripathi et al., J Immunol 2010 (Lymphocytic Choriomeningitis) : In this study, we assessed the role of IL-7, IL-15 , and their common signal transducer, STAT5, in maintaining effector CD4 ( + ) and CD8 ( + ) T cell responses ... In contrast, effector CD4 ( + ) T cell numbers were not affected by the individual or combined loss of IL-15 and IL-7
Vandergeeten et al., Blood 2013 (HIV Infections) : When administered to HIV infected subjects receiving suppressive ART, interleukin-7 (IL-7) increases the number of CD4 ( + ) T cells by promoting their survival and proliferation
Suzuki et al., J Virol 1999 : Among them, interleukin-12 (IL-12) and IL-4 induce naive CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively