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EGF — SETD2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SETD2 → EGF (increases) Olsen et al., Cell 2006*
  Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Mabjeesh et al., Clin Cancer Res 2003 (Prostatic Neoplasms) : HIF-1 activation by DHT was blocked by LY294002, a potent inhibitor of the phosphatidylinositol 3'-kinase signaling pathway, whereas HIF-1 activation by EGF , as ligand, was not inhibited by flutamide
Wheeler et al., Oncogene 2010 (Carcinoma, Squamous Cell...) : Further investigation showed that EGF induced expression of the STAT3 target gene HIF1-a , was abolished by cetuximab in HNSCC cells expressing wild-type EGFR under hypoxic conditions, but not in EGFRvIII expressing HNSCC cells
Weber et al., Radiation oncology (London, England) 2012 (Prostatic Neoplasms) : Additionally, epithelial growth factor (EGF) mediates HIF1a production
Cheng et al., Cancer Lett 2013 (Ovarian Neoplasms) : We show that EGF treatment induces HIF-1a expression in two human ovarian cancer cell lines ( SKOV3 and OVCAR5 ), and that this effect is diminished by treatment with a membrane-permeable H ( 2 ) O ( 2 ) scavenger, PEG-catalase ... However, the induction of HIF-1a by EGF did not require the activation of p38 MAPK ... Treatment with siRNA targeting HIF-1a reduces both basal and EGF induced HIF-1a levels
Shin et al., PloS one 2013 (Neovascularization, Pathologic...) : Mechanistically, MEL specifically inhibited the EGF induced HIF-1a expression by suppressing the phosphorylation of ERK, mTOR and p70S6K ... It also blocked the EGF induced DNA binding activity of HIF-1a and the secretion of the vascular endothelial growth factor ( VEGF )