◀ Back to E2F1
E2F1 — HDAC3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
HDAC3 (HDAC3)
→
RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Lai et al., Mol Cell Biol 1999
Evidence: physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
HDAC3 (HDAC3)
→
RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Lai et al., Mol Cell Biol 1999
Evidence: physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Lai et al., Mol Cell Biol 1999
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Boutillier et al., J Neurochem 2003
:
Taken together, our results suggest that, in neuroprotective conditions,
histone deacetylase activity
allows a constitutive repression of the
e2f-1 gene in mature neurones in order to ensure survival
Park et al., Biochem Biophys Res Commun 2012
:
Here, we identified and characterized a regulatory region of Lhx2 gene which mediates responses to two different signals such as inhibition of
HDAC3 and
stimulation by
E2F1