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EGF — HGS
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
HGS
→
EGF
(increases)
Urbé et al., J Cell Sci 2003*
Evidence: We have analysed Hrs phosphorylation in response to epidermal growth factor (EGF) stimulation and show that the evolutionary conserved tyrosines Y329 and Y334 provide the principal phosphorylation sites.
-
Reactome Reaction:
EGF
→
HGS
(indirect_complex)
Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Haglund et al., EMBO Rep 2005
-
Reactome Reaction:
EGF
→
HGS
(reaction)
Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005
Text-mined interactions from Literome
Bache et al., Eur J Biochem 2002
(Carcinoma, Hepatocellular...) :
Stimulation of cells with
epidermal growth factor (EGF) rapidly
leads to phosphorylation of
Hrs , raising the question whether the receptor tyrosine kinase phosphorylates Hrs directly
Urbé et al., J Cell Sci 2003
:
We have analysed
Hrs phosphorylation in
response to
epidermal growth factor (EGF) stimulation and show that the evolutionary conserved tyrosines Y329 and Y334 provide the principal phosphorylation sites ... We show that the same UIM domain is necessary for
EGF stimulated tyrosine phosphorylation of
Hrs
Scoles et al., Biochem Biophys Res Commun 2005
(Neurilemmoma) :
HRS inhibits
EGF receptor signaling in the RT4 rat schwannoma cell line
Stern et al., Mol Cell Biol 2007
:
Using an HEK 293 model system, we found that ectopic expression of the protein Cbl enhances Hrs ubiquitination and
increases Hrs phosphorylation following cell stimulation with
EGF
Meijer et al., Cell Signal 2012
:
EGF stimulation of the EGFR
resulted in efficient
Hrs tyrosine phosphorylation and deubiquitination by the K63-polyubiquitin chain-specific deubiquitinating enzyme AMSH