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TGFB1 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Liao et al., Acta Pharmacol Sin 2001
:
TGF-beta1 induced
p53 expression but not Bax
Wong et al., J Biol Chem 2002
:
A novel p53 transcriptional repressor element ( p53TRE ) and the asymmetrical contribution of two p53 binding sites modulate the
response of the placental
transforming growth factor-beta promoter to
p53
Negulescu et al., Kidney Int 2002
:
The
effects of
TGF-beta1 on mesangial cell apoptosis,
p53 phosphorylation, Bax and Bcl-2 levels, caspase 9 activity, and cleavage of PARP were examined ...
TGF-beta1 induced
p53 activation and all the intermediary steps leading to mesangial cell apoptosis were reversed by estradiol ( 10-9 mol/L ) and by DRB, potent inhibitors of CK2 activity, but not by inhibitors of the p38 MAPK, ERK or JNK signaling cascades
Kokkinakis et al., Mol Cancer Ther 2005
(Adenocarcinoma...) :
Inhibition of cell cycle progression correlates with loss of hyperphosphorylated Rb and up-regulation of p21 via
p53 and/or
transforming growth factor-beta ( TGF-beta )
activation depending on p53 status
Zhang et al., Cell cycle (Georgetown, Tex.) 2006
:
TGFbeta1 induced activation of ATM and
p53 mediates apoptosis in a Smad7 dependent manner
Wiegman et al., Radiother Oncol 2007
:
TGFbeta-1 dependent fast stimulation of ATM and
p53 phosphorylation following exposure to ionizing radiation does not involve TGFbeta-receptor I signalling ... We confirm that
TGFbeta-1 plays a critical role in the stimulation of ATM- and
p53 signalling in irradiated cells
Kalo et al., Mol Cell Biol 2007
:
We found that mutant
p53 attenuates
TGF-beta1 signaling
Paterson et al., Br J Cancer 1995
(Carcinoma, Squamous Cell...) :
TGF-beta 1 did not
affect p53 mRNA expression in both tumour derived and normal keratinocytes and there was no alteration in p53 protein levels in keratinocytes expressing stable p53 protein following TGF-beta 1 treatment
Selvakumaran et al., Oncogene 1994
(Leukemia, Myeloid, Acute) :
Thus, the p53 mediated up-regulation of Bax may provide at least a partial explanation for the more rapid rate of apoptosis
induced by
p53 compared to by
TGF beta 1 , as well as for the ineffectiveness of ectopoic Bcl-2 to abrogate p53 mediated apoptosis
Joiakim et al., Am J Respir Cell Mol Biol 1993
:
Ca2+ had no significant effect on cell proliferation, but it enhanced the expression of
TGF-beta 1 gene and slightly
inhibited p53 expression
Landesman et al., Cell Signal 1997
:
In this study we examined whether
p53 and two other cycle inhibitory genes that can be transactivated by p53 are
affected by
TGF-beta 1 in epithelial cells
Sugiyama et al., Biochem Biophys Res Commun 1997
:
We investigated the
effects of
TGF-beta1 on cyclin D1, cyclin A, p21, p27, and
p53 mRNA expressions in primary cultured rat hepatocytes by the reverse-transcription polymerase chain reaction ( RT-PCR ) method