◀ Back to RELA

CFTR — RELA

Text-mined interactions from Literome

Brouillard et al., J Biol Chem 2001 : NF-kappa B mediates up-regulation of CFTR gene expression in Calu-3 cells by interleukin-1beta ... Transfection experiments using -2150 to +52 CFTR reporter gene constructs showed that the activity of the CFTR promoter is enhanced by exogenous transfected NF-kappaB and IL-1beta and that this enhancement is due, at least in part, to the -1103 to -1093 kappaB site
Melotti et al., Gene Ther 2001 (Cystic Fibrosis...) : All these inhibitors abolished both Ad.CFTR induced NF-kB DNA binding and transactivating activities
Knorre et al., Biol Chem 2002 (Cystic Fibrosis...) : DeltaF508-CFTR causes constitutive NF-kappaB activation through an ER-overload response in cystic fibrosis lungs
Schroeder et al., Proc Natl Acad Sci U S A 2002 : CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation
Kowalski et al., J Immunol 2004 (Pseudomonas Infections) : Bacterial binding leads to CFTR dependent bacterial internalization, initiation of NF-kappaB nuclear translocation, cellular desquamation, and eventual apoptosis of the infected cells, all of which are critical for innate immune resistance to infection with this pathogen
Zaidi et al., Invest Ophthalmol Vis Sci 2004 (Anoxia...) : Changes in binding and internalization of P. aeruginosa were measured using cellular association and gentamicin-exclusion assays, and expression of CFTR and activation of NF-kappaB in response to hypoxia were determined by confocal laser microscopy and quantitative measurements of NF-kappaB activation ... Hypoxia increased CFTR expression and NF-kappaB nuclear translocation in rabbit and human cells with wild-type CFTR
Hybiske et al., Am J Physiol Lung Cell Mol Physiol 2007 (Calcium Signaling...) : We tested whether cystic fibrosis ( CF ) airway epithelia have larger innate immune responses than non-CF or cystic fibrosis transmembrane conductance regulator ( CFTR ) -corrected cells, perhaps resulting from ER stress due to retention of DeltaF508CFTR in the endoplasmic reticulum ( ER ) and activation of cytosolic Ca ( 2+ ) ( Ca(i) ) and nuclear factor (NF)-kappaB signaling
Boncoeur et al., Am J Pathol 2008 : In this study, we evaluated the role of CFTR in the control of ubiquitin-proteasome activity and nuclear factor (NF)-kappaB/IkappaB-alpha signaling after lung oxidative stress ... In this study, we evaluated the role of CFTR in the control of ubiquitin-proteasome activity and nuclear factor (NF)-kappaB/IkappaB-alpha signaling after lung oxidative stress
Kelly et al., J Pharmacol Exp Ther 2010 : CFTR ( inh ) -172, but not GlyH-101, induced nuclear translocation of nuclear factor-kappaB (NF-kappaB)
Xu et al., PloS one 2010 : Reduction of CFTR expression in AM resulted in increased secretion of IL-8, increased phosphorylation of NF-kappaB , a positive regulator of IL-8 expression, and decreased expression of IkappaB-alpha, the inhibitory protein of NF-kappaB activation
Hunter et al., PloS one 2010 (Inflammation) : CFTR channel activity may be necessary for this suppression because the CFTR specific inhibitor CFTR ( inh172 ) significantly stimulates NF-kappaB activity by approximately 30 % in CFTR expressing 16HBE14o- cells whereas pharmacological elevation of cyclic-AMP depresses activity by approximately 25 % below baseline