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IRAK2 — TRAF6

Pathways - manually collected, often from reviews:

• BioCarta signal transduction through il1r: IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → TRAF6 (modification, activates)
• KEGG Neurotrophin signaling pathway: Complex of IRAK1-IRAK2-IRAK3-IRAK4-TRAF6 → IKBKB (protein-protein, activation)
• KEGG Tuberculosis: IRAK1/IRAK2 → TRAF6 (protein-protein, activation)
• Reactome Reaction: IRAK2 → TRAF6 (reaction) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Ono et al., J Biol Chem 2001, Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Keating et al., J Biol Chem 2007, Muroi et al., J Leukoc Biol 2008, Shibuya et al., Science 1996, Cao et al., Nature 1996
• Reactome Reaction: IRAK2 → TRAF6 (indirect_complex) Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Keating et al., J Biol Chem 2007, Muroi et al., J Leukoc Biol 2008, Cao et al., Nature 1996
• Reactome Reaction: IRAK2 → TRAF6 (direct_complex) Lamothe et al., J Biol Chem 2007
• WikiPathways Regulation of toll-like receptor signaling pathway: TRAF6 → IRAK2 (unknown)
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): IRAK2 → TRAF6 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: IRAK2 — TRAF6 (coimmunoprecipitation) Wesche et al., J Biol Chem 1999
• IRef Biogrid Interaction: IRAK2 — TRAF6 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: IRAK2 — TRAF6 (physical association, affinity chromatography technology) Wesche et al., J Biol Chem 1999
• IRef Biogrid Interaction: IRAK2 — TRAF6 (physical association, affinity chromatography technology) Muzio et al., Science 1997
• IRef Biogrid Interaction: IRAK2 — TRAF6 (physical association, affinity chromatography technology) Keating et al., J Biol Chem 2007
• IRef Biogrid Interaction: IRAK2 — TRAF6 (physical association, affinity chromatography technology) Li et al., Immunity 2011
• IRef Hprd Interaction: IRAK2 — TRAF6 (in vivo) Muzio et al., Science 1997
• IRef Innatedb Interaction: Complex of TRAF6-IRAK2-TRAF2 (unknown, -) Li et al., Immunity 2011
• IRef Innatedb Interaction: IRAK2 — TRAF6 (unknown, -) Boch et al., Biochem Biophys Res Commun 2003*
• IRef Innatedb Interaction: IRAK2 — TRAF6 (unknown, -) Wesche et al., J Biol Chem 1999
• IRef Innatedb Interaction: IRAK2 — TRAF6 (unknown, -) Muzio et al., Science 1997
• IRef Intact Interaction: Complex of 18 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
• IRef Intact Interaction: IRAK2 — TRAF6 (physical association, anti tag coimmunoprecipitation) Wesche et al., J Biol Chem 1999
• IRef Intact Interaction: IRAK2 — TRAF6 (physical association, two hybrid array) Wang et al., Molecular systems biology 2011
• IRef Ophid Interaction: IRAK2 — TRAF6 (aggregation, confirmational text mining) Boch et al., Biochem Biophys Res Commun 2003*
• IRef Ophid Interaction: IRAK2 — TRAF6 (aggregation, confirmational text mining) Muzio et al., Science 1997
• IRef Ophid Interaction: IRAK2 — TRAF6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Qian et al., J Biol Chem 2001 : IRAK mediated translocation of TRAF6 and TAB2 in the interleukin-1 induced activation of NFkappa B
Keating et al., J Biol Chem 2007 : Expression of IRAK-2 , but not IRAK-1, led to TRAF6 ubiquitination, an event critical for NFkappaB activation