Gene interactions and pathways from curated databases and text-mining

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ESR2 — STAT5B

Text-mined interactions from Literome

Frasor et al., Mol Endocrinol 2001 : Interestingly, either Stat5a or Stat5b could stimulate ERalpha transcription while stimulation of ERbeta occurred only in the presence of Stat5b ... These findings indicate that PRL stimulation of ER expression occurs at the level of transcription and that PRL regulation of ERalpha can be mediated by either Stat5a or Stat5b, while regulation of ERbeta appears to be mediated only by Stat5b
Frasor et al., Trends Endocrinol Metab 2003 : A single nucleotide difference between these two response elements is responsible for the observation that either Stat5a or Stat5b can stimulate Esr1 transcription, whereas only Stat5b can activate transcription of Esr2