Gene interactions and pathways from curated databases and text-mining

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AHR — EPHB2

Text-mined interactions from Literome

Chen et al., J Biol Chem 2005 : ERK kinase inhibition stabilizes the aryl hydrocarbon receptor : implications for transcriptional activation and protein degradation
Cheon et al., Exp Mol Med 2007 (MAP Kinase Signaling System) : PD153035, an EGFR inhibitor, as well as alpha-NF significantly reduced ERK phosphorylation, suggesting that ERK activation by TCDD was mediated by both EGFR and AhR
Xie et al., Am J Physiol Gastrointest Liver Physiol 2012 (Colonic Neoplasms) : With the use of two human colon cancer cell lines, H508 and SNU-C4, we examined the effects of AhR ligands including 2,3,7,8-tetrachlorodibenzo-p-dioxin ( TCDD ) on cell proliferation and activation of EGFR, ERK1/2 , and Src kinases
Pontillo et al., Toxicol Appl Pharmacol 2013 (Mammary Neoplasms, Experimental...) : We have found that HCB activates c-Src/HER1/STAT5b and HER1/ERK1/2 signaling pathways and cell migration, in an AhR dependent manner in MDA-MB-231 breast cancer cells