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HDAC2 — NFKB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
HDAC2
—
NFKB1
(physical association, affinity chromatography technology)
Sun et al., J Biol Chem 2007
-
Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Xiao et al., J Biol Chem 2000
:
Consistently, when expressed alone, the
NRD potently
inhibits NIK mediated
NF-kappaB signaling
Ashburner et al., Mol Cell Biol 2001
:
HDAC2 does not interact with NF-kappaB directly but can
regulate NF-kappaB activity through its association with HDAC1
Rahman et al., Biochem Pharmacol 2002
(Pneumonia) :
Pharmacological inhibition of
HDAC leads to the increased HAT activity, AP-1 and
NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments
Mayo et al., J Biol Chem 2003
(Carcinoma, Non-Small-Cell Lung...) :
Because the anti-apoptotic transcription factor NF-kappa B has been shown to be under the control of HDAC mediated repression, we analyzed whether
HDAC inhibitors
activated NF-kappa B in NSCLC cells ...
HDAC inhibitors effectively
stimulated endogenous
NF-kappa B-dependent gene expression by up-regulating IL-8, Bcl-XL, and MMP-9 transcripts
Foss et al., Leukemia & lymphoma 2003
(Lymphoma, T-Cell, Cutaneous) :
Other novel agents include the interleukin (IL)-2 fusion toxin ( ONTAK ), pentostatin ( a potent adenosine deaminase inhibitor ),
histone deacetylase inhibitors such as depsipeptide,
NF-kappaB inhibitors , cytokine receptor antagonists, immunomodulatory therapies and allogeneic stem cell therapy
Singh et al., Oncogene 2005
(Breast Neoplasms) :
HDAC inhibitors
synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through
NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Place et al., Biochem Pharmacol 2005
:
HDAC inhibition
prevents NF-kappa B activation by suppressing proteasome activity : down-regulation of proteasome subunit expression stabilizes I kappa B alpha
Shetty et al., Mol Cell Biol 2005
(Breast Neoplasms) :
Indeed,
HDAC inhibitors
activate NF-kappaB and p53 and upregulate DR5 expression
Graham et al., Cell cycle (Georgetown, Tex.) 2005
:
In addition,
HDAC inhibitors
induce NFkappaB binding to the DR5 gene and DR5 expression, contributing to HDAC inhibitor induced apoptosis
Ito et al., J Exp Med 2006
(Pulmonary Disease, Chronic Obstructive) :
Loss of
HDAC2 did not reduce GR nuclear translocation, GR binding to glucocorticoid response element ( GRE ) on DNA, or GR-induced DNA or gene induction but
inhibited the association between GR and
NF-kappaB
Kammanadiminti et al., J Biol Chem 2006
(Colitis) :
Overexpression of wild type Hsp27 amplified the effects of SAP, whereas a phosphorylation-deficient mutant of Hsp27 abrogated
SAP induced
NF-kappaB inhibition
Kim et al., Biochem Biophys Res Commun 2006
:
Involvement of HDAC1 and the PI3K/PKC signaling pathways in
NF-kappaB activation by the
HDAC inhibitor apicidin ... Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not
HDAC2 , 3 or 4, dramatically
inhibits NF-kappaB reporter gene activity
Andresen et al., J Immunol 2007
:
NF-kappaB activity can be
induced by
HDAC treatment
Glauben et al., Gut 2008
(Colitis...) :
As for potential mechanisms of ITF2357 action, increased acetylation of histone 3, reduced production of IFN gamma and enhanced apoptosis in lamina propria mononuclear cells were found to accompany a
histone deacetylase dependent
activation of
NF-kappaB
Kaler et al., Exp Cell Res 2008
(Colonic Neoplasms) :
We showed that overexpression of
HDAC2 enhanced TNFalpha induced
NF-kappaB activity and that silencing of HDAC2 decreased NF-kappaB activity
Hayes et al., Eur J Nutr 2008
(Neoplasms) :
In particular, their abilities to induce cytoprotective genes, mediated by the Nrf2 ( NF-E2 related factor 2 ) and AhR ( arylhydrocarbon receptor ) transcription factors, and their abilities to repress
NF-kappaB ( nuclear factor-kappaB ) activity,
inhibit histone deacetylase , and inhibit cytochrome P450 are outlined
Chavey et al., Mol Pharmacol 2008
(Breast Neoplasms) :
In summary, our results demonstrate that
NF-kappaB pathway
repression by
HDAC is responsible for the low expression of IL-8 in ERalpha positive breast cancer cells
Farhana et al., Mol Cancer Ther 2009
:
We examined the
effect of loss of SHP and
Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated
nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression
Zhang et al., Am J Physiol Heart Circ Physiol 2010
(Disease Models, Animal...) :
Luciferase assay demonstrated an
activation of
NF-kappaB by
HDAC inhibition