UCSC Genome Browser Gene Interaction Graph

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to CRK

CRK — PTPN11

Pathways - manually collected, often from reviews:

NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → None (modification, activates) Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001
Evidence: mutant phenotype, assay, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → None (modification, activates) Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001
Evidence: mutant phenotype, assay, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → RAP1/GDP complex (RAP1B_RAP1A) (modification, activates)
Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001
Evidence: mutant phenotype, assay, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → RAP1/GTP complex (RAP1B_RAP1A) (modification, activates)
Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001
Evidence: mutant phenotype, assay, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → GAB2 (GAB2) (modification, collaborate) Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001, Tanaka et al., Proc Natl Acad Sci U S A 1994
Evidence: physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → C3G (RAPGEF1) (modification, collaborate) Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001, Tanaka et al., Proc Natl Acad Sci U S A 1994
Evidence: physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family/C3G/GAB2 complex (FRS3_FRS2-CRKL_CRK-PTPN11-RAPGEF1-GAB2) → FRS2 family/SHP2/CRK family complex (FRS3_FRS2-CRKL_CRK-PTPN11) (modification, collaborate)
Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001, Tanaka et al., Proc Natl Acad Sci U S A 1994
Evidence: physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: GAB2 (GAB2) → FRS2 family/SHP2/CRK family complex (FRS3_FRS2-CRKL_CRK-PTPN11) (modification, collaborate)
Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001, Tanaka et al., Proc Natl Acad Sci U S A 1994
Evidence: physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: C3G (RAPGEF1) → FRS2 family/SHP2/CRK family complex (FRS3_FRS2-CRKL_CRK-PTPN11) (modification, collaborate)
Kao et al., J Biol Chem 2001, Wu et al., J Neurosci 2001, Tanaka et al., Proc Natl Acad Sci U S A 1994
Evidence: physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family complex (FRS3_FRS2-CRKL_CRK-PTPN11) → CRK family (CRKL/CRK) (modification, collaborate) Kao et al., J Biol Chem 2001
Evidence: physical interaction
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/CRK family complex (FRS3_FRS2-CRKL_CRK-PTPN11) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, collaborate)
Kao et al., J Biol Chem 2001
Evidence: physical interaction
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: CRK family (CRKL/CRK) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, collaborate)
Kao et al., J Biol Chem 2001
Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: PTPN11 — CRK (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
IRef Hprd Interaction: Complex of 73 proteins (in vivo) Schulze et al., Molecular systems biology 2005
IRef Intact Interaction: Complex of 13 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009

Text-mined interactions from Literome

Ruhul Amin et al., Cancer Res 2003 (MAP Kinase Signaling System) : Finally, reintroduction of wild-type SHP-2 into SHP-2 mutant cells rescued Erk and p38 activation, and also MMP-2 secretion, whereas dominant negative SHP-2 could block the Con A-dependent activation of Erk and p38
Fang et al., PloS one 2012 : Signaling regulatory mechanism investigation using immunoblotting, immunoprecipitation, and GST pull-down assay reveals that the down-regulation of Shp2 expression in RBL cells leads to decreased activities of Fyn, PLC?, JNK, p38MAPK , and Ras/Erk1/2 after FceR? aggregation