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ARHGEF2 — EPHB2

Text-mined interactions from Literome

Fujishiro et al., Biochem Biophys Res Commun 2008 : We have examined whether ERK1/2 are involved in the phosphorylation of GEF-H1 , a GEF toward RhoA, to modulate its activity
Waheed et al., Am J Physiol Cell Physiol 2010 : This conclusion is based on our findings that 1 ) depolarization activated GEF-H1 but not p115RhoGEF, 2 ) short interfering RNA mediated GEF-H1 silencing eliminated the activation of the Rho pathway, and 3 ) ERK inhibition prevented the activation of GEF-H1
Kakiashvili et al., J Biol Chem 2011 (MAP Kinase Signaling System) : We have previously shown that ERK mediated stimulation of the RhoA GDP/GTP exchange factor GEF-H1/Lfc is critical for TNF-a induced RhoA stimulation ... EGF treatment mimicked the effects of TNF-a, as it elicited potent, ERK dependent GEF-H1 and RhoA activation
Guilluy et al., Nat Cell Biol 2011 : Our results reveal that LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras