Ji et al., J Neurosci 2002
(Disease Models, Animal...) :
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
Campillo et al., Mol Pharmacol 2010
(Pain, Postoperative) :
These findings suggest that activated ERK1/2 could induce c-Fos expression and trigger the transcription of prodynorphin in the spinal cord