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SOD1 — SOD3
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Wei et al., J Neurosci Res 2003
:
We found that : ( 1 ) the decrease in cell viability induced by hydrogen peroxide was attenuated in PC12 cells pretreated with olanzapine ; ( 2 ) olanzapine increased SOD enzyme activity in PC12 cells ; ( 3 ) inhibiting
SOD activity with diethyldithiocarbamic acid
prevented the cytoprotective actions of olanzapine ; and ( 4 ) the decrease in
SOD-1 mRNA level induced by hydrogen peroxide was blocked by pretreatment with olanzapine
Grzenkowicz-Wydra et al., Mol Cell Biochem 2004
:
Overexpression of human
SOD1 in mouse NIH 3T3 fibroblasts
increased SOD activity, enhanced intracellular generation of H2O2 and significantly stimulated VEGF production as determined by increase in VEGF promoter activity, VEGF mRNA expression and VEGF protein synthesis
Smyth et al., Int J Exp Pathol 2009
(Drug-Induced Liver Injury) :
In the dose response study, serum
SOD activity was elevated in all CCl ( 4 ) -treated animals and urinary
SOD-1 activity was
increased 2.2 times at the lowest dose ( 0.10 ml/kg ) and 60.4 times at the highest CCl ( 4 ) dose level ( 0.80 ml/kg )
Greenough et al., J Biol Chem 2011
(Alzheimer Disease) :
Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of
SOD1 dependent copper/zinc
superoxide dismutase activity
Rottner et al., PloS one 2011
(Cystic Fibrosis) :
These observations underscore a reduced anti-oxidant defense mechanism, at least in part, via diminished
EC-SOD activity and
regulation of
Cu/Zn-SOD and Mn-SOD expressions
Giusti et al., Free radical research 2012
:
Haplotypes reconstruction showed that SOD1 ( GG ) decreased the risk of RDS, IVH and ROP
; SOD2 ( GT )
increased the risk of BPD and decreased the risk of RDS, IVH and ROP ;
SOD3 ( TGC ) decreased the risk of BPD and IVH ; and 4 ) CAT ( CTC ) decreased the risk of RDS ... Haplotypes reconstruction showed that
SOD1 ( GG ) decreased the risk of RDS, IVH and ROP
; SOD2 ( GT )
increased the risk of BPD and decreased the risk of RDS, IVH and ROP ; SOD3 ( TGC ) decreased the risk of BPD and IVH ; and 4 ) CAT ( CTC ) decreased the risk of RDS
Poggi et al., The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2012
(Premature Birth) :
Haplotypes reconstruction showed that SOD1 ( GG ) decreased the risk of RDS, IVH and ROP
; SOD2 ( GT )
increased the risk of BPD and decreased the risk of RDS, IVH, and ROP ;
SOD3 ( TGC ) decreased the risk of BPD and IVH ; and CAT ( CTC ) decreased the risk of RDS ... Haplotypes reconstruction showed that
SOD1 ( GG ) decreased the risk of RDS, IVH and ROP
; SOD2 ( GT )
increased the risk of BPD and decreased the risk of RDS, IVH, and ROP ; SOD3 ( TGC ) decreased the risk of BPD and IVH ; and CAT ( CTC ) decreased the risk of RDS
Jerusalem et al., Neurology 1996
(Amyotrophic Lateral Sclerosis) :
The
involvement of
superoxide dismutase in sporadic
ALS is unclear