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CDK2 — ORC2

Pathways - manually collected, often from reviews:

• Reactome Reaction: CDK2 → ORC2 (indirect_complex) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999
• Reactome Reaction: CDK2 → ORC2 (reaction) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999, Méndez et al., Mol Cell 2002

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CDK2 — ORC2 Ramachandran et al., Science 2004
• IRef Bind_translation Interaction: CDK2 — ORC2 (array technology) Ramachandran et al., Science 2004
• IRef Biogrid Interaction: ORC2 — CDK2 (direct interaction, pull down) Ramachandran et al., Science 2004
• IRef Biogrid Interaction: ORC2 — CDK2 (direct interaction, enzymatic study) Méndez et al., Mol Cell 2002
• IRef Hprd Interaction: CDK2 — ORC2 (in vitro) Ramachandran et al., Science 2004
• IRef Intact Interaction: ORC2 — CDK2 (direct interaction, protein array) Ramachandran et al., Science 2004
• IRef Intact Interaction: Complex of CCNA2-CCNA1-ORC1-CDK2-ORC2 (association, coimmunoprecipitation) Méndez et al., Mol Cell 2002
• IRef Ophid Interaction: ORC2 — CDK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Findeisen et al., Eur J Biochem 1999 : We find that chromatin binding of ORC , Cdc6, and MCM proteins does not require cyclin dependent kinase activities
Machida et al., J Biol Chem 2005 : These results demonstrate an unexpected role of ORC2 in CDK2 activation, a linkage that could be important for maintaining genomic stability
Fernández-Cid et al., Mol Cell 2013 : Importantly, CDK dependent phosphorylation of ORC inhibits OCM establishment to ensure once per cell cycle replication