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E2F1 — PHB

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PHB — E2F1 (physical association, affinity chromatography technology) Wang et al., EMBO J 2002*
• IRef Biogrid Interaction: PHB — E2F1 (physical association, affinity chromatography technology) Joshi et al., Biochem Biophys Res Commun 2003*
• IRef Biogrid Interaction: PHB — E2F1 (direct interaction, pull down) Joshi et al., Biochem Biophys Res Commun 2003*
• IRef Biogrid Interaction: PHB — E2F1 (colocalization, imaging technique) Fusaro et al., J Biol Chem 2003*
• IRef Biogrid Interaction: PHB — E2F1 (physical association, affinity chromatography technology) Fusaro et al., J Biol Chem 2003*
• IRef Biogrid Interaction: PHB — E2F1 (direct interaction, pull down) Wang et al., Mol Cell Biol 1999*
• IRef Biogrid Interaction: PHB — E2F1 (physical association, affinity chromatography technology) Wang et al., Mol Cell Biol 1999*
• IRef Biogrid Interaction: PHB — E2F1 (physical association, affinity chromatography technology) Wang et al., EMBO J 2004*
• IRef Dip Interaction: PHB — E2F1 (physical association, coimmunoprecipitation) Wang et al., EMBO J 2002*
• IRef Hprd Interaction: PHB — E2F1 (in vitro) Wang et al., Mol Cell Biol 1999*, Joshi et al., Biochem Biophys Res Commun 2003*
• IRef Hprd Interaction: PHB — E2F1 (in vivo) Wang et al., Mol Cell Biol 1999*, Joshi et al., Biochem Biophys Res Commun 2003*
• IRef Ophid Interaction: PHB — E2F1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., Oncogene 1999 : Surprisingly, prohibitin mediated repression of E2F could not be reversed by adenovirus E1A protein ... A prohibitin mutant that could not bind to Rb was impaired in its ability to repress E2F activity and inhibit cell proliferation
Wang et al., Mol Cell Biol 1999 : We recently observed that prohibitin , a potential tumor suppressor protein, binds to the retinoblastoma ( Rb ) protein and represses E2F transcriptional activity ... Prohibitin was also found to interact with the signaling kinase c-Raf-1, and Raf-1 could effectively reverse prohibitin mediated repression of E2F activity ... Agents such as E1A, p38 kinase, and cyclins D and E had no effect on prohibitin mediated repression of E2F1 , but all of these molecules could reverse Rb function
Wang et al., EMBO J 2002 : Expression of a dominant negative Brg-1 or Brm releases prohibitin mediated repression of E2F and relieves prohibitin mediated growth suppression
Fusaro et al., J Biol Chem 2003 : Prohibitin , a potential tumor suppressor protein, has been shown to inhibit cell proliferation and repress E2F transcriptional activity
Joshi et al., Biochem J 2007 : Further, depletion of E2F1 prevented prohibitin from repressing the YY1 promoter
Choi et al., Oncogene 2008 : Herein, we report that prohibitin interacts with RING finger protein 2 (RNF2), a member of the PcG ( polycomb-group ) family of proteins, and that the two proteins regulate the activity of E2F1 via dual pathways : the direct, prohibitin mediated pathway and the indirect, p16 mediated pathway of E2F1 transcriptional regulation ... Furthermore, the depletion of either endogenous RNF2 or prohibitin using the RNA interference technique increased the level of p16 protein expression, resulting in a decrease in the transcriptional activity of E2F1 via the p16-CDK4-Rb pathway ... These results suggest that the RNF2-prohibitin complex regulates the activity of E2F1 via dual pathways