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NCOR1 — VDR
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
VDR
—
NCOR1
(direct interaction, pull down)
Herdick et al., J Mol Biol 2000*
-
IRef Biogrid Interaction:
VDR
—
NCOR1
(direct interaction, two hybrid)
Tagami et al., Biochem Biophys Res Commun 1998*
-
IRef Biogrid Interaction:
VDR
—
NCOR1
(direct interaction, pull down)
Puccetti et al., Cancer Res 2002*
-
IRef Biogrid Interaction:
VDR
—
NCOR1
(physical association, affinity chromatography technology)
Fujiki et al., EMBO J 2005
-
IRef Biogrid Interaction:
VDR
—
NCOR1
(direct interaction, pull down)
Kim et al., Mol Endocrinol 2009*
-
IRef Biogrid Interaction:
VDR
—
NCOR1
(direct interaction, two hybrid)
Kim et al., Mol Endocrinol 2009*
-
IRef Biogrid Interaction:
VDR
—
NCOR1
(direct interaction, two hybrid)
Polly et al., FASEB J 2000*
Text-mined interactions from Literome
Herdick et al., J Mol Biol 2000
:
This study demonstrates that the interaction of the VDR with
NCoR results in a preferential stabilization of the
VDR in a non-agonistic conformation ( silent state ), whereas within a complex with SRC-1 VDR is in its agonistic conformation ( activated state )
Banwell et al., J Steroid Biochem Mol Biol 2004
(Breast Neoplasms) :
Proliferation of the non-malignant breast epithelial cell line, MCF-12A, is sensitively and completely inhibited by 1alpha,25-dihydroxyvitamin D ( 3 ) ( 1alpha,25 ( OH ) ( 2 ) D ( 3 ) ) ( ED90 = 70 nM ), We used real time RT-PCR to demonstrate that the relative resistance to 1alpha,25 ( OH ) ( 2 ) D ( 3 ) of MDA-MB-231 cells ( ED50 > 100 nM ) correlated with significantly reduced
Vitamin D receptor (VDR) and
increased NCoR1 nuclear receptor co-repressor mRNA ( 0.1-fold reduction in VDR and 1.7-fold increase in NCoR1 relative to MCF-12A ( P < 0.05 ) )
Banwell et al., Clin Cancer Res 2006
(Breast Neoplasms) :
Altered
nuclear receptor corepressor expression
attenuates vitamin D receptor signaling in breast cancer cells