◀ Back to MAP3K5
MAP2K6 — MAP3K5
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAP2K6
→
MAP3K5
(directlyIncreases, MAP2K6 Activity)
Evidence: Moreover, ASK1 phosphorylates and activates MKK3 and MKK6
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
MEK6 (MAP2K6)
(modification, activates)
-
BioCarta mapkinase signaling pathway:
ASK1/TAK1/MAP3K11 (MAP3K5/MAP3K11/MAP3K7)
→
MEK3/MEK6 (MAP2K3/MAP2K6)
(modification, activates)
-
KEGG MAPK signaling pathway:
MAP3K5
→
MAP2K6
(protein-protein, phosphorylation)
-
KEGG Amyotrophic lateral sclerosis (ALS):
MAP3K5
→
MAP2K6
(protein-protein, activation)
-
Reactome Reaction:
MAP3K5
→
MAP2K6
(reaction)
Takekawa et al., Mol Cell 2005*, Ichijo et al., Science 1997
-
WikiPathways 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression:
Complex of MAP2K6-MAP2K3
→
MAP3K5
(activation)
-
WikiPathways p38 MAPK Signaling Pathway:
MAP3K5
→
MAP2K6
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
MAP3K5
—
MAP2K6
Takekawa et al., Mol Cell 2005*
-
IRef Bind_translation Interaction:
MAP3K5
—
MAP2K6
(two hybrid)
Takekawa et al., Mol Cell 2005*
-
IRef Biogrid Interaction:
MAP3K5
—
MAP2K6
(direct interaction, two hybrid)
Takekawa et al., Mol Cell 2005*
-
IRef Biogrid Interaction:
MAP3K5
—
MAP2K6
(direct interaction, enzymatic study)
Mo et al., J Cell Biochem 2010*
-
IRef Biogrid Interaction:
MAP3K5
—
MAP2K6
(direct interaction, pull down)
Huang et al., Mol Cell 2003*
-
IRef Biogrid Interaction:
MAP3K5
—
MAP2K6
(direct interaction, enzymatic study)
Morita et al., EMBO J 2001*
-
IRef Hprd Interaction:
MAP3K5
—
MAP2K6
(two hybrid)
Takekawa et al., Mol Cell 2005*
Text-mined interactions from Literome
Tu et al., Cell Signal 2003
:
They consist of a three-kinase module in which a mitogen activated protein kinase kinase kinase (
MAP3K )
activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn activates MAPK
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a
MAP3K phosphorylates and
activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )