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PTGS1 — TNF
Text-mined interactions from Literome
Yucel-Lindberg et al., J Dent Res 1999
:
Neither IL-1beta,
TNFalpha , nor the combination of these two cytokines
affected COX-1 mRNA levels
Subbarayan et al., Cancer Res 2001
(Prostatic Neoplasms) :
Because COX-2 levels were low in prostate smooth muscle cells, prostate stromal cells, and tumor cells, we also examined whether
COX-1 and COX-2 gene expression was elevated in
response to
tumor necrosis factor-alpha (TNF-alpha) , a strong inducer of COX-2 expression
Yamada et al., Clin Exp Immunol 2002
(Urinary Bladder Neoplasms) :
NS398, a specific COX-2 inhibitor, and indomethacin ( IM ), a
COX-1 and COX-2 inhibitor,
enhanced viable BCG induced cytotoxic activity and IFN-gamma and
TNF-alpha production of PEC
Jiang et al., Mol Cell Biochem 2003
:
In this study, the
effect of phorbol 12-myristate 13-acetate ( PMA ),
tumor necrosis factor alpha (TNFalpha), lipopolysaccharide (LPS) and macrophage-colony stimulating factor ( M-CSF ) on AA release and prostaglandin E2 ( PGE2 ) production and the expression of cPLA2 and
COX-1 and -2 were investigated in U937 human pre-monocytic cells and fully differentiated macrophages
Tsai et al., Int Immunopharmacol 2004
:
Interleukin (IL)-1beta ( 25 ng/ml ), IL-8 ( 25 ng/ml ), growth related oncogene-alpha ( GRO, 50 ng/ml ) and
tumor necrosis factor-alpha ( TNF-alpha, 25 ng/ml )
stimulated the
COX-1 protein production as demonstrated by Western blot and enhanced PGE2 synthesis in GMC, beginning on 2 h of incubation, and steadily enhanced TXB2 synthesis over a 24-h period
Diaz et al., Exp Cell Res 1998
:
Analysis of fibroblast proteins showed the induction of
cyclooxygenase-1 (Cox-1) by TGF-beta 1 and the
induction of Cox-2 by IL-1 beta and
TNF-alpha