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CCND1 — LPA

Text-mined interactions from Literome

Hu et al., J Natl Cancer Inst 2003 (Carcinoma...) : LPA stimulated cyclin D1 promoter activity ( 3.0-fold, 95 % confidence interval [ CI ] = 2.7-fold to 3.3-fold ) ... In addition to the previously characterized indirect mechanism that increases angiogenesis via VEGF, LPA may directly increase the level of cyclin D1 in ovarian cancer cells, increasing their proliferation
Lin et al., Am J Physiol Gastrointest Liver Physiol 2010 (Adenoma...) : In vitro studies using HCT116 cells showed that LPA induced cyclin D1 , c-Myc, and HIF-1a expression, which was attenuated by knockdown of LPA ( 2 )
Kim et al., Mol Cells 2012 (Carcinoma, Embryonal...) : Furthermore, LPA up-regulated CRE harboring cyclin D1 promoter activity, suggesting that CREB and cyclin D1 play significant roles in LPA induced proliferation of P19 embryonic carcinoma cells
Rai et al., J Exp Med 2012 (Neoplasms) : In vivo, the administration of soluble RAGE or genetic deletion of RAGE mitigated LPA stimulated vascular Akt signaling, autotaxin/LPA-driven phosphorylation of Akt and cyclin D1 in the mammary tissue of transgenic mice vulnerable to carcinogenesis, and ovarian tumor implantation and development