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MAPK14 — PLCG1
Text-mined interactions from Literome
Kornmann et al., Gastroenterology 2002
(Cell Transformation, Neoplastic...) :
In vitro, TAKA-1 cells stably transfected with FGFR-1 IIIc exhibited increased basal growth ; enhanced basal tyrosine phosphorylation of FGFR substrate-2 (FRS2), Shc, and
phospholipase Cgamma ; and increased
activation of
mitogen activated protein kinase ( MAPK )
Chen et al., J Biol Chem 2002
:
Incubation of cells with the specific EGFR inhibitor AG4178 blocked MbetaCD induced phosphorylation of EGFR, SHC,
phospholipase C-gamma , and Gab-1 as well as
MAPK activation
Kwon et al., J Cell Biol 2003
:
Expression of the PH-EF construct blocked endogenous
PLCgamma1 binding to the IR and
inhibited insulin dependent phosphorylation of
mitogen activated protein kinase ( MAPK ), but not AKT ... Silencing
PLCgamma1 expression using small interfering RNA markedly
reduced insulin dependent
MAPK regulation in HepG2 cells
Rong et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Here, we report that the phospholipase activity of
PLC-gamma1 plays an essential role in nerve growth factor (NGF) triggered
Raf/MEK/MAPK pathway activation in PC12 cells ... These observations indicate that the lipase activity of
PLC-gamma1 mediates NGF regulated
MAPK signaling upstream of Ras/Rap1 activation probably through second messenger DAG activated Ras and Rap-GEFs
Luo et al., J Clin Invest 2004
:
Further downstream, in the absence of EphB6, ZAP-70 activation, LAT phosphorylation, the association of
PLCgamma1 with SLP-76, and p44/42
MAPK activation were diminished
Shen et al., J Mol Cell Cardiol 2007
:
PLCgamma1 activation by LPS also
increased ERK1/2
MAPK phosphorylation, and inhibition of ERK1/2 MAPK blocked the effect of PLCgamma1 on COX-2 expression
Zheng et al., J Neurochem 2008
(Ion Channel Gating) :
Although previous studies suggested the roles of
mitogen activated protein kinase ,
phospholipase C-gamma mediated intracellular calcium ( [ Ca2+ ] i )
increase , and extracellular calcium influx in regulating Akt activation, the cellular mechanisms are largely unknown
Marra et al., J Clin Invest 1996
:
IFN-gamma pretreatment did not influence PDGF or EGF receptor autophosphorylation,
activation of
phospholipase Cgamma1 , and phosphatidylinositol 3-kinase, or
mitogen activated protein kinase activity