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CYBA — CYBB

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: None → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1 (increases)
  Rinckel et al., Biochem Biophys Res Commun 1999*
  Evidence: Upon stimulation, a functional NADPH oxidase is assembled when the cytosolic proteins, Rac, p67phox, p47phox, and possibly p40phox, associate with the gp91phox and p22phox transmembrane proteins.
• OpenBEL Selventa BEL large corpus: None → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1 (increases, Activity)
  
  Evidence: PKC is known to induce cellular reactive oxygen species (ROS) and PKC-dependent activation of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH oxidase has recently been shown to be responsible, in part, for increased oxidative stress in diabetes.
• KEGG Phagosome: CYBA → CYBB/NOX1/NOX3 (protein-protein, binding/association)
• KEGG Phagosome: CYBA → CYBB/NOX1/NOX3 (protein-protein, binding/association)
• KEGG Leukocyte transendothelial migration: VCAM1 → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 (enzyme-enzyme, activation)
  
• KEGG Leukocyte transendothelial migration: Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 → MMP2/MMP9 (enzyme-enzyme, activation)
• KEGG Leukocyte transendothelial migration: Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 → MAPK11/MAPK12/MAPK13/MAPK14 (enzyme-enzyme, activation)
  
• KEGG Leukocyte transendothelial migration: RAC1 → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 (protein-protein, activation)
  
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → p47 Phox/p67 Phox/cytochrome b-245/RAC1/GTP complex (NCF1-NCF2-RAC1-CYBB-CYBA) (modification, collaborate)
  Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → RAC1/GTP complex (RAC1) (modification, collaborate) Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245/RAC1/GTP complex (NCF1-NCF2-RAC1-CYBB-CYBA) → RAC1/GTP complex (RAC1) (modification, collaborate) Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → cytochrome b-245 complex (CYBB-CYBA) (modification, collaborate)
  Roepstorff et al., J Biol Chem 2008
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → p47 Phox/p67 Phox complex (NCF1-NCF2) (modification, collaborate)
  Roepstorff et al., J Biol Chem 2008
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: cytochrome b-245 complex (CYBB-CYBA) → p47 Phox/p67 Phox complex (NCF1-NCF2) (modification, collaborate)
  Roepstorff et al., J Biol Chem 2008
  Evidence: physical interaction
• Reactome Reaction: CYBA → CYBB (direct_complex)
• WikiPathways Microglia Pathogen Phagocytosis Pathway: CYBB → NCF1/NCF4/NCF2/RAC1/RAC2/RAC3/CYBB/CYBA (mim-conversion)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: Complex of CYBB-CYBA-TNFRSF1A-RFK-NOX1-RAC1 (anti bait coimmunoprecipitation) Yazdanpanah et al., Nature 2009
• IRef Hprd Interaction: Complex of 33 proteins (in vivo) Grizot et al., Biochemistry 2001*, Li et al., J Biol Chem 2002, Leto et al., Proc Natl Acad Sci U S A 1994, Sathyamoorthy et al., J Biol Chem 1997*
• IRef Hprd Interaction: CYBB — CYBA (in vivo) Li et al., J Biol Chem 2002, Leto et al., Proc Natl Acad Sci U S A 1994
• IRef Hprd Interaction: CYBB — CYBA (in vitro) Li et al., J Biol Chem 2002, Leto et al., Proc Natl Acad Sci U S A 1994
• IRef Ophid Interaction: CYBB — CYBA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Dusi et al., Eur J Immunol 2001 : Our results indicate that in monocytes the IFN-gamma- and TNF-alpha induced expression of gp91phox and p22phox , but not p47phox, requires the binding of PU.1 to gp91phox promoter
Wandall et al., Aliment Pharmacol Ther 1991 (Translocation, Genetic) : Superoxide anion production requires translocation of a cytochrome b-245 and this translocation was reduced by sulphasalazine ( P less than 0.01 ) but not by 5-ASA or sulphapyridine
Zhu et al., J Biol Chem 2006 : The results demonstrate that p22phox dependent maturation of gp91phox carbohydrate, cell surface expression of gp91phox , and the enzymatic function of flavocytochrome b558 are closely correlated
Cassatella et al., J Clin Invest 1989 (Granulomatous Disease, Chronic...) : Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells ... Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells
Marshall et al., Am J Respir Cell Mol Biol 1996 (Anoxia) : Together these observations demonstrate that the unique cytochrome b-245 containing NADPH-oxidase is present in pulmonary artery smooth muscle and that an NADPH-oxidase or NADH-oxidoreductase complex is activated to release superoxide by hypoxic conditions