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CYBB — IFNG
Text-mined interactions from Literome
Conte et al., J Interferon Cytokine Res 1999
(Granulomatous Disease, Chronic...) :
In
chronic granulomatous disease ,
interferon-gamma (IFN-gamma) significantly
reduces the incidence and severity of recurrent infections, but its effectiveness administered ex novo during acute infection has been reported in only one case
Eklund et al., J Immunol 1999
:
Recruitment of CREB binding protein by PU.1, IFN-regulatory factor-1, and the IFN consensus sequence binding protein is necessary for
IFN-gamma induced p67phox and
gp91phox expression ... Previously, we identified a CYBB cis element, necessary for
IFN-gamma induced
gp91phox expression, and also activated by this transcription factor combination ... Because
IFN-gamma induces simultaneous expression of p67phox and
gp91phox , these investigations identify a molecular event that coordinates oxidase gene transcription during the inflammatory response
Dusi et al., Eur J Immunol 2001
:
Our results indicate that in monocytes the
IFN-gamma- and TNF-alpha induced expression of gp91phox and p22phox, but not p47phox,
requires the binding of PU.1 to
gp91phox promoter
Kumatori et al., J Biol Chem 2002
:
Cooperation of STAT-1 and IRF-1 in
interferon-gamma induced transcription of the
gp91(phox) gene ...
Interferon (IFN)-gamma induces the expression of the
gp91(phox) gene both during myeloid differentiation and also in mature phagocytes through several cis-elements and their binding proteins ... These results demonstrate a new mechanism for
IFN-gamma induced transcription of the
gp91(phox) gene by the cooperation of STAT-1alpha and IRF-1 binding to -100GAS and -88ISRE, respectively
Lopez et al., J Interferon Cytokine Res 2003
:
The aim of this study was to investigate the
effect of
interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and
gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage
Mazzi et al., J Immunol 2004
:
IFN-gamma induces
gp91phox expression in human monocytes via protein kinase C-dependent phosphorylation of PU.1 ... We previously reported that the stimulation of human blood monocytes with
IFN-gamma induces the binding of PU.1 to the gp91(phox) promoter and the consequent expression of
gp91(phox) ... This phosphorylation, as well as the
IFN-gamma induced PU.1 binding and
gp91(phox) protein synthesis, is slightly affected by the casein kinase II inhibitor, daidzein, but is abrogated by the protein kinase C (PKC) -alpha and -beta inhibitor, Go6976, and by synthetic peptides with sequences based on the endogenous pseudosubstrate region of the classical PKC alpha and beta isoforms ... Finally, nuclear run-on assays demonstrated that while the PKC inhibitors, Go6976 and LY333531, decrease the
IFN-gamma induced
gp91(phox) transcription, the serine phosphatase inhibitor, okadaic acid, enhances the gp91(phox) gene transcription ... Our results indicate that in cultured monocytes,
IFN-gamma induces the binding of PU.1 to the gp91(phox) promoter and the expression of
gp91(phox) by phosphorylation of PU.1 via activation of PKC alpha and/or beta I
Kakar et al., J Leukoc Biol 2005
:
In these studies, we determine Janus tyrosine kinase 2 (JAK2) activation is necessary and sufficient for
IFN-gamma induced
CYBB transcription in phagocytic cells and also for ICSBP and HoxA10 tyrosine phosphorylation ... Therefore, these findings provide direct demonstration of JAK2 dependence of
IFN-gamma induced
CYBB transcription
Almeida et al., J Interferon Cytokine Res 2005
:
The aim of this work was to analyze the
effect of
Interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and
gp91-phox gene expression in human colostrum macrophages ( CM ), peripheral blood monocytes ( PBM ), and myelomonocytic THP-1 cells ... Thus,
IFN-gamma and TNF-alpha
induced equivalent
gp91-phox gene expression in THP-1 cells compared with CM or PBM but did not bring about equivalent NADPH oxidase activity
Lindsey et al., J Immunol 2005
:
In
response to
IFN-gamma , phosphorylation of two tyrosine residues in the HoxA10 homeodomain decreases binding to
CYBB promoter, thereby abrogating HoxA10 mediated repression
Anrather et al., J Biol Chem 2006
:
In monocytic and microglial cell lines, the expression of the NADPH oxidase subunit
gp91(phox) was
induced by
lipopolysaccharide/interferon gamma treatment and was inhibited in cells constitutively expressing IkappaBalpha
Dohi et al., Journal of neuroinflammation 2010
(Brain Injuries) :
In the
presence of
IFNgamma , BV-2 cells had increased inducible nitric oxide synthase and nitric oxide levels, consistent with a classical activated phenotype, and drastically increased expression of
gp91phox
Cassatella et al., J Biol Chem 1990
:
These results suggest that
induction of the
gp91-phox gene and protein product by
IFN-gamma or LPS is an important requirement in the mechanism of the enhancement of neutrophil and macrophage oxidative metabolism
Cassatella et al., J Clin Invest 1989
(Granulomatous Disease, Chronic...) :
Tumor necrosis factor and
immune interferon synergistically
induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells
Eklund et al., J Immunol 1996
:
Characterization of three promoter elements and cognate DNA binding protein ( s ) necessary for
IFN-gamma induction of
gp91-phox transcription
Eklund et al., J Biol Chem 1997
(Leukemia, Myeloid) :
CYBB is transcriptionally inactive until the promyelocyte stage of myelopoiesis, and in mature phagocytes, expression of gp91(phox) is further
increased by
interferon-gamma (IFN-gamma) and other inflammatory mediators
Eklund et al., J Biol Chem 1998
:
An element in the proximal CYBB promoter binds a protein complex, referred to as hematopoiesis associated factor ( HAF1 ), that is necessary for
interferon-gamma (IFNgamma) induced
gp91(phox) expression