◀ Back to EFNA1
EFNA1 — EPHA1
Pathways - manually collected, often from reviews:
-
KEGG Axon guidance:
EFNA1/EFNA2/EFNA3/EFNA4/EFNA5
→
EPHA1/EPHA2/EPHA3/EPHA4/EPHA5/EPHA6/EPHA7/EPHA8
(protein-protein, activation)
-
NCI Pathway Database EPHA forward signaling:
EPHA1-4 (EPHA2/EPHA1/EPHA3/EPHA4)
→
Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4)
(modification, collaborate)
Gale et al., Neuron 1996
Evidence: physical interaction
-
NCI Pathway Database EPHA forward signaling:
EPHA1-4 (EPHA2/EPHA1/EPHA3/EPHA4)
→
Ephrin A1 (EFNA1)
(modification, collaborate)
Gale et al., Neuron 1996
Evidence: physical interaction
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4)
→
Ephrin A1 (EFNA1)
(modification, collaborate)
Gale et al., Neuron 1996
Evidence: physical interaction
-
NCI Pathway Database EPHA forward signaling:
None
→
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
(modification, collaborate)
Shamah et al., Cell 2001
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
→
RHOA/GTP complex (RHOA)
(modification, activates)
Shamah et al., Cell 2001
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Shamah et al., Cell 2001
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
→
None
(modification, activates)
Shamah et al., Cell 2001
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4)
→
Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, activates)
Walker-Daniels et al., Mol Cancer Res 2002, Sharfe et al., J Immunol 2003
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
→
Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4)
(modification, collaborate)
Shamah et al., Cell 2001, Sahin et al., Neuron 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
→
Ephexin (NGEF)
(modification, collaborate)
Shamah et al., Cell 2001, Sahin et al., Neuron 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4)
→
Ephexin (NGEF)
(modification, collaborate)
Shamah et al., Cell 2001, Sahin et al., Neuron 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4)
→
Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Shamah et al., Cell 2001, Sahin et al., Neuron 2005
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
EFNA1
→
EPHA1
(direct_complex)
Himanen et al., Nature 2001, Himanen et al., Trends Neurosci 2003, Himanen et al., Curr Opin Cell Biol 2007, Himanen et al., EMBO Rep 2009
-
Reactome Reaction:
EFNA1
→
EPHA1
(reaction)
Marignani et al., J Cell Biol 2001, Himanen et al., Nature 2001, Himanen et al., Trends Neurosci 2003, Marston et al., Nat Cell Biol 2003, Cowan et al., Neuron 2005, Himanen et al., Curr Opin Cell Biol 2007, Himanen et al., EMBO Rep 2009
-
Reactome Reaction:
EFNA1
→
EPHA1
(indirect_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
EPHA1
—
EFNA1
(experimental interaction detection)
Gale et al., Neuron 1996
-
IRef Hprd Interaction:
EPHA1
—
EFNA1
(in vitro)
Coulthard et al., Growth Factors 2001*, Gale et al., Neuron 1996
-
IRef Hprd Interaction:
EPHA1
—
EFNA1
(in vivo)
Coulthard et al., Growth Factors 2001*, Gale et al., Neuron 1996
-
IRef Ophid Interaction:
EPHA1
—
EFNA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
EPHA1
—
EFNA1
(aggregation, confirmational text mining)
Coulthard et al., Growth Factors 2001*
Text-mined interactions from Literome
Nie et al., Nat Neurosci 2010
:
We also found that
EphA receptor
activation by
ephrin-A ligands in neurons led to inhibition of extracellular signal regulated kinase 1/2 ( ERK1/2 ) activity and decreased inhibition of Tsc2 by ERK1/2
Petty et al., PloS one 2012
(Neoplasm Metastasis...) :
During tumor progression,
EphA2 receptor can gain ligand independent pro-oncogenic functions due to Akt activation and
reduced ephrin-A ligand engagement