◀ Back to NOS3

EDN1 — NOS3

Text-mined interactions from Literome

Marsen et al., Pflugers Arch 1999 : Tyrosine-kinase dependent regulation of the nitric oxide synthase gene by endothelin-1 in human endothelial cells
Barton et al., J Am Soc Nephrol 2000 (Glomerulosclerosis, Focal Segmental...) : Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and Glomerulosclerosis
Schwerte et al., J Exp Biol 2002 : We used novel digital contrasting methods to measure the effects of endothelin-1 ( ET-1, 10 ( -6 ) to 10 ( -8 ) mol l ( -1 ) ), the nitric-oxide releasing agent sodium nitroprusside ( SNP, 10 ( -2 ) mol l ( -1 ) ) and N ( omega ) -nitro-L-arginine methyl ester hydrochloride ( L-NAME, 10 ( -4 ) mol l ( -1 ) ), a non-selective inhibitor of nitric oxide synthase , on the diameter of tiny arteries and veins of the head in anaesthetized Xenopus laevis tadpoles ( stage NF 50-53 )
Ye et al., Hypertension 2003 : We asked whether endothelin might play a role in the control of basal or osmotically regulated NPR-A or eNOS gene expression in these cells ... Increased extracellular tonicity reduced endothelin mRNA accumulation in these cells ( approximately 15 % of control levels ) ; however, exogenous endothelin failed to normalize osmotically increased NPR-A activity or expression, or osmotically suppressed eNOS expression
Liu et al., J Biol Chem 2003 : Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt
Luo et al., Am J Physiol Gastrointest Liver Physiol 2004 (Hepatopulmonary Syndrome...) : Both increased hepatic endothelin-1 (ET-1) production and pulmonary vascular ET ( B ) receptor expression with stimulation of endothelial nitric oxide synthase and TNF-alpha mediated inducible nitric oxide synthase and heme oxygenase-1 expression in pulmonary intravascular macrophages occur
Merkel et al., Microcirculation 2005 (Inflammation) : LPS inhibits endothelin-1 mediated eNOS translocation to the cell membrane in sinusoidal endothelial cells ... The objectives of this study were to develop a model for studying endothelin-1 mediated eNOS regulation in cultured sinusoidal endothelial cells and determine the effect of endothelin-1 and endotoxin ( LPS ) on eNOS localization ... Endothelin-1 stimulated eNOS translocation to the cell membrane ... Pretreatment with LPS markedly inhibited the endothelin-1 mediated eNOS translocation
Zhang et al., Acta Pharmacol Sin 2005 (Hypertension, Pulmonary) : In the PAH group, the endothelin-1 (ET-1) in serum and lungs was dramatically increased by 54 % ( 79.9 pg/mL, P < 0.01 ) and 93 % ( 166.2 pg/mL, P < 0.01 ), and mRNA levels of preproET-1, eNOS , and iNOS also increased dramatically compared with control
Ohlstein et al., J Neurosurg 1992 : An l-arginine analog inhibitor of nitric oxide synthase , L-NG-monomethyl arginine ( L-NMMA, 200 microM ), did not significantly affect basal immunoreactive endothelin levels
Kamoun et al., Hepatology 2006 : LPS inhibits endothelin-1 induced endothelial NOS activation in hepatic sinusoidal cells through a negative feedback involving caveolin-1
Novella et al., Eur J Cardiothorac Surg 2007 (Cardiovascular Diseases) : No change in the AVP response was produced by endothelium removal, exposure to the NO precursor ( 3 x 10 ( -4 ) M L-arginine ), inhibition of nitric oxide ( NO ) synthase ( 3 x 10 ( -5 ) M L-NAME ) or soluble guanylate cyclase ( 3 x 10 ( -6 ) M 1H- [ 1,2,4 ] oxadiazol [ 4,3,-alpha ] quinoxalin-1-one ( ODQ ) ), removal of the superoxide anion ( 100 U/ml superoxide dismutase ( SOD ) plus 1200 U/ml catalase ) or hydroxyl radical ( 10 ( -4 ) M deferoxamine ), or specific alpha1 - ( 10 ( -6 ) M prazosin ) or endothelin ( 10 ( -5 ) M bosentan ) receptor antagonism
Chandrasekar et al., Pediatr Res 2008 (Disease Models, Animal...) : PPHN was associated with decreases in eNOS and ET-B receptor and increase in prepro-endothelin mRNA levels
Herrera et al., J Biol Chem 2009 : Endothelin-1 increased phosphorylation of NOS3 at Ser1177 by 89 +/- 24 % ( p < 0.01 ; n = 7 ) but had no effect on Ser633
Kwok et al., Shock 2010 : Because Cav-1 binds and inhibits eNOS, it was suggested that Cav-1 overexpression inhibits endothelin 1 (ET-1) mediated eNOS activation after endotoxemia in the liver ; however, a causal link between stress mediated suppression of eNOS and Cav-1 overexpression has not been fully established
Kwok et al., Am J Physiol Gastrointest Liver Physiol 2009 : Caveolin-1 mediates endotoxin inhibition of endothelin-1 induced endothelial nitric oxide synthase activity in liver sinusoidal endothelial cells ... Endothelin-1 (ET-1) plays a key role in the regulation of endothelial nitric oxide synthase (eNOS) activation in liver sinusoidal endothelial cells ( LSECs )
Fujita et al., Eur J Pharmacol 1995 (Disease Models, Animal...) : We examined the effect of long-term nitric oxide ( NO ) synthase inhibition on vascular and renal endothelin-1 levels and evaluated the antihypertensive effect of endothelin ETA receptor antagonist FR139317 ( ( R ) 2 ( - ) [ ( R ) -2 ( - ) [ ( S ) -2 ( - ) [ [ 1- ( hexahydro-1H-azepinyl ) ] - carbonyl ] amino-4-methyl-pentanoyl ] amino-3 ( - ) [ 3- ( 1-methyl-1H- indolyl ) ] propionyl ] amino-3- ( 2-pyridyl ) proprionic acid ] on rats in which NO synthase was blocked
Beck et al., Kidney Int 1995 : Endothelin-1 inhibits cytokine stimulated transcription of inducible nitric oxide synthase in glomerular mesangial cells
Edwards et al., Am J Obstet Gynecol 1996 (Body Weight...) : We postulated that long-term nitric oxide synthase inhibition with L-nitro-arginine methyl ester would induce sustained hypertension, a rise in plasma levels of endothelin-1 , and fetal growth restriction ... Long-term nitric oxide synthase blockade causes sustained hypertension, elevated levels of endothelin-1 , and fetal growth restriction
Hirahashi et al., Pharmacology 1996 : Endothelin-1 inhibits induction of nitric oxide synthase and GTP cyclohydrolase I in rat mesangial cells
Lin et al., Eur J Endocrinol 1998 : Role of nitric oxide synthase in release of endothelin from cultured human endometrial cells
Gude et al., Clin Exp Pharmacol Physiol 1998 : 2. Vasoconstriction responses to 5-hydroxytryptamine ( 5-HT ) were potentiated in the presence of endothelin-1 (ET-1) , the thromboxane A2-mimetic U46619 and a nitric oxide synthase inhibitor , N-nitro-L-arginine ( NOLA ), but not in the presence of angiotensin II