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CDKN1A — MAP2K1

Text-mined interactions from Literome

Kivinen et al., Cell Growth Differ 1999 : We demonstrate that p21 induction by PDGF and TGF-beta1 requires MEK1 ( /2 ) and, additionally, that the TGF-beta1 effect on p21 depends on Ras, whereas the PDGF effect does not
Beier et al., J Biol Chem 1999 (MAP Kinase Signaling System) : The chemical MEK1/2 inhibitor PD98059 reduced protein levels of p21 in MCTs and primary mouse chondrocytes
Eblen et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : It was previously shown that Rac-p21 activated kinase (PAK) signaling regulated the physical association of MEK1 with ERK2 through phosphorylation sites in the proline-rich sequence (PRS) of MEK1
Lunghi et al., Blood 2004 (Leukemia, Erythroblastic, Acute) : We found that MEK1 inhibitors reduce the levels of dominant negative ( DeltaN ) p73 proteins and promote the accumulation of endogenous p73alpha through its transcriptional activation and its tyrosine phosphorylation, resulting in p21 up-regulation and significant inhibition of cell growth
Ciccarelli et al., Molecular cancer 2005 (MAP Kinase Signaling System...) : Furthermore, the TPA mediated post-transcriptional mechanism of p21WAF1 enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2, which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression
Lotan et al., Cancer Res 2008 (Neoplasm Metastasis...) : c-Jun NH2-terminal kinase activating kinase 1/mitogen activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation
Zhang et al., J Biol Chem 2008 : Parallel to cell death processes, overexpression of p21 or p27 profoundly enhanced DCA + MEK1/2 inhibitor induced expression of ATG5 and GRP78/BiP and phosphorylation of PKR-like endoplasmic reticulum kinase ( PERK ) and eIF2alpha, and it increased the numbers of vesicles containing a transfected LC3-GFP construct
Ding et al., J Gastroenterol Hepatol 2008 (Helicobacter Infections...) : MEK1/2 inhibition increased p21 , p27 and cyclin E and JNK inhibition additionally increased cyclin D1 expression
Zezula et al., J Biol Chem 1997 : The bFGF mediated increase in p21cip1 is blocked by the Mek1 inhibitor, but not by GF109203X ; hence, in endothelial cells, induction of p21cip1 by PKC- and growth factor dependent signaling is achieved by distinct pathways that converge and require activation of the mitogen activated protein kinase cascade