Liu et al., J Exp Med 2003
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Thus, IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of IL-12 p35 transcription in synergy with LPS mediated events
Lehtonen et al., Cytokine 2003
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Both IFN-alpha and IL-12 strongly up-regulated IRF-1, IRF-4 , and IRF-8 mRNA and protein expression
Xiong et al., J Biol Chem 2005
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Furthermore, IRF-8 induced IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production