◀ Back to CTNNB1
CTNNB1 — SIAH1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Iwai et al., Oncogene 2004
:
Siah-1L , a novel transcript variant belonging to the human Siah family of proteins,
regulates beta-catenin activity in a p53 dependent manner ... Thus,
Siah-1L represents a new member of the human Siah family that is induced in response to p53 and
plays an important role in the regulation of
beta-catenin activity in tumor cells
Kim et al., Oncogene 2004
(Stomach Neoplasms) :
The
effect of
Siah-1 on
beta-catenin degradation was further examined in wild- and mutant-type Siah-1 transfected HEK 293T cells
Jang et al., Proc Natl Acad Sci U S A 2005
(Lymphoma, B-Cell) :
We show that inhibition of endogenous
Siah-1 stabilizes and
activates beta-catenin in B cells
Park et al., Mol Pharmacol 2006
(Colonic Neoplasms) :
Our findings suggest that hexachlorophene attenuates Wnt/beta-catenin signaling through the
Siah-1 mediated
beta-catenin degradation
Mei et al., Oncogene 2007
:
Siah-1S, a novel splice variant of Siah-1 ( seven in absentia homolog ), counteracts
Siah-1 mediated downregulation of
beta-catenin
Xie et al., J Cell Mol Med 2009
:
Moreover, repression of
beta-catenin/TCF activity by E2F1 can be
attenuated by shRNA based repression of endogenous
Siah1 , implying that Siah1 is a bona fide E2F1 target gene, which at least partly, mediates the suppression of beta-catenin/TCF signalling pathway