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CRYAB — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CRYAB — TP53 (physical association, affinity chromatography technology) Jin et al., J Cell Biochem 2009*
• IRef Biogrid Interaction: CRYAB — TP53 (physical association, affinity chromatography technology) Watanabe et al., Cancer Sci 2009*

Text-mined interactions from Literome

Liu et al., Biochem Biophys Res Commun 2007 : alphaB-Crystallin interacted with p53, a proapoptotic protein, during cell apoptosis and such protein interaction mainly occurred in the cytoplasm of the cells, suggesting that the interaction of alphaB-crystallin with p53 might prevent the translocation of p53 from cytoplasm to mitochondria
Evans et al., Breast Cancer Res Treat 2010 (Carcinoma, Transitional Cell...) : Induction of the small heat shock protein alphaB-crystallin by genotoxic stress is mediated by p53 and p73 ... DeltaNp73 was dramatically induced by p53 in a TAp73 dependent manner, and silencing p73 suppressed the transcriptional activation of alphaB-crystallin by p53
Deng et al., BMB Rep 2010 : Transient transfection assays indicated that overexpression of LBH or alphaB-crystallin reduced the transcriptional activities of p53 and p21, respectively, Overexpression of both alphaB-crystallin and LBH together resulted in a stronger repression of the transcriptional activities of p21 and p53 ... These results showed that the interaction of LBH and alphaB-crystallin may inhibit synergistically the transcriptional regulation of p53 and p21