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FOXM1 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Li et al., J Biol Chem 2008
:
Induction of
FoxM1c expression markedly
suppressed senescence and expression of
p53 and p21
Barsotti et al., Oncogene 2009
(Neoplasms) :
In this study we show that
p53 is
required for the downregulation of
FoxM1 , an essential transcription factor that regulates many G2/M-specific genes and is overexpressed in a multitude of solid tumors ... Nutlin, a small-molecule activator of
p53 ,
suppresses FoxM1 levels in two cell lines in which DNA damage facilitates only mild repression ... Mechanistically,
p53 mediated inhibition of
FoxM1 is partially p21 and retinoblastoma ( Rb ) family dependent, although in some cases p21 independent repression of FoxM1 was also observed ... Finally, our results indicate a potential contribution of
p53 mediated repression of
FoxM1 for maintenance of a stable G2 arrest
Millour et al., Mol Cancer Ther 2011
(Breast Neoplasms) :
ATM and
p53 regulate
FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance ... In summary, our data show that ATM and
p53 coordinately
regulate FOXM1 via E2F to modulate epirubicin response and resistance in breast cancer
Qu et al., Cancer Lett 2013
(Carcinoma, Hepatocellular...) :
Negative
regulation of transcription factor
FoxM1 by
p53 enhances oxaliplatin induced senescence in hepatocellular carcinoma