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PGC — TP53

Text-mined interactions from Literome

Villeneuve et al., Antioxid Redox Signal 2013 (Cardiomyopathy, Dilated...) : Innovation and Conclusion : We provide the first evidence that MAO-A upregulation in the heart causes oxidative mitochondrial damage, p53 dependent repression of PGC-1a , cardiomyocyte necrosis, and chronic ventricular dysfunction
Aquilano et al., Antioxid Redox Signal 2013 : We show that p53 mediated PGC-1a upregulation is directed to potentiate the antioxidant defense through nuclear factor ( erythroid derived 2 ) -like2 ( NFE2L2 ) -mediated expression of manganese superoxide dismutase ( SOD2 ) and ?-glutamylcysteine ligase without modulating mitochondrial biogenesis