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EGF — MMP2

Text-mined interactions from Literome

Reddy et al., Int J Cancer 1999 (Breast Neoplasms...) : In contrast, when SKBR-3 cells were exposed to MEK inhibitor ( PD 98059 ) or MAPK inhibitors ( Apigenin or MAPK antisense phosphorothioate oligodeoxynucleotides ), EGF induced cell proliferation, MMP-9 induction and invasion through reconstituted basement membrane were significantly reduced
Sundareshan et al., Prostate 1999 (Adenocarcinoma...) : Induction of the MMP , matrilysin, by epidermal growth factor (EGF) was investigated in a human prostate cancer cell line
Huang et al., Br J Pharmacol 1999 (Neoplasm Metastasis) : 8. This study demonstrates that the inhibitory effects of Lu and Qu, and the stimulatory effects of EGF , on tumour cell proliferation, cellular protein phosphorylation, and MMP secretion may be mediated at least partly through EGFR
Huang et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : LHRH reduced both basal and EGF stimulated secretion of MMP-9 and MMP-2
Domeij et al., Eur J Oral Sci 2002 (MAP Kinase Signaling System) : In addition, MMP-1 and MMP-3 production, induced by IL-1beta, TNFalpha or EGF , was strongly reduced by the presence of the glucocorticoid dexamethasone
Yang et al., Gastroenterology 2003 (Liver Cirrhosis) : Stimulation of HSCs with platelet derived growth factor (PDGF)-BB, transforming growth factor (TGF)-beta1, and/or epithelial growth factor (EGF) resulted in an increase in their migratory capacity and up-regulated matrix metalloproteinase (MMP)-2 activity
Nutt et al., BJU Int 2003 (Urinary Bladder Neoplasms) : MMP9 was induced by EGF in the RT112 but not the RT4 bladder tumour cell line, whereas MMP2 production was unaffected by EGF ... EGF induces MMP9 but not MMP2 in bladder cells
Kobayashi et al., Acta Derm Venereol 2003 : Moreover, TGF-beta1, TNF-alpha, or epidermal growth factor augmented the secretion of MMP-2 from fibroblasts
Bredin et al., Anticancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : IGF I, IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9
Vesey et al., Kidney Int 2005 (Calcium Signaling...) : These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation, the autocrine action of thrombin induced TGF-beta1 secretion, MMP activation, or EGF receptor transactivation
Ahmed et al., Am J Physiol Cell Physiol 2006 (Cell Transformation, Neoplastic) : EGF increased cell motility, enhanced the activities of secreted pro-matrix metalloproteinase (MMP)-2 and -9, and enhanced expression and activation of Erk and integrin linked kinase (ILK) ... EGF withdrawal resulted in a more epithelial morphology and reversal of the EGF induced activation of signaling pathways and pro-MMP activity ... The inhibitors caused suppression of EGF induced migration and pro-MMP-2/-9 activities but did not lead to any change in EGF induced mesenchymal morphology
Jiang et al., J Ocul Pharmacol Ther 2006 : Furthermore, we found that EGF induced activity of matrix metalloproteinase-2 (MMP-2) in cultured HLECs ... EGF induced MMP-2 activity was significantly inhibited by treatment of PD153035, U0126, and LY294002, but not SB203580 and JNK inhibitor, suggesting that ERK and the phosphatidylinositol-3-kinase (PI3K)/AKT pathways selectively mediate EGF stimulated MMP-2 activity and cell migration in cultured HLECs in vitro
Cury et al., Arch Oral Biol 2007 : The gene expression of MMP-2 , TIMP-1 and 2 was not affected by EGF ( p < 0.05 )
Binker et al., Biochem Biophys Res Commun 2009 (Neoplasm Invasiveness...) : Using specific inhibitors, we found that EGF stimulation of these tumor cells induced secretion and activation of the collagenase MMP-2 , which was required for EGF stimulated basement membrane degradation and cell invasion
Park et al., Am J Physiol Cell Physiol 2009 : EGF also increased matrix metalloproteinase ( MMP-2 ) expression levels and EGF induced MMP2 expression was inhibited by caveolin-1 siRNA, FAK siRNA, LY-294002, Akt inhibitor, and PD-98059
Yu et al., Cytotechnology 2009 : Matrine significantly reduced the invasion, MMP-9/MMP-2 activation , Akt phosphorylation, nuclear factor kappaB p-65 expression and DNA binding activity, and mRNA levels of MMP-9, MMP-2, EGF and VEGFR1 in MDA-MB-231 cells
Zhang et al., Int J Gynecol Cancer 2009 (Carcinoma...) : We showed here that EGF induced the expression of MT1-MMP and inhibited the expression of MMP-2 at both the mRNA and protein levels ... Our results suggest that EGF receptor up-regulated the expression of MT1-MMP and down-regulated the synthesis of MMP-2 through the mitogen activated protein kinase/extracellular signal regulated kinase pathway while concomitantly transmitting a mild positive regulatory signal to the expression of MMP-2 via the PI3-K/AKT pathway in SiHa cells
Staun-Ram et al., Placenta 2009 : p53 Mediates epidermal growth factor (EGF) induction of MMP-2 transcription and trophoblast invasion ... MMP-2 expression was induced by EGF within 1 hour ... Inhibition of p53 by antisense reduced both basic and EGF- induced MMP-2 expression ... p53 mediates both basic and EGF induced MMP-2 transcription
Pan et al., Invest Ophthalmol Vis Sci 2011 : Hypertonicity induced EGF receptor (EGFR) transactivation was suppressed by preincubating HCECs with capsazepine, matrix metalloproteinase 1 (MMP1) inhibitor TIMP-1, broad-spectrum MMP inhibitor GM 6001, heparin bound (HB)-EGF inhibitor CRM 197, or EGFR inhibitor AG 1478
Xu et al., Biochem Biophys Res Commun 2010 (Ovarian Neoplasms) : Functionally, combined stimulation of TGFß and EGF enhances the mobility of OVCA429 cells and induces the production of MMP2 by OVCA429 cells more potently than either alone
Hwang et al., Mol Nutr Food Res 2011 (Fibrosarcoma...) : Capsaicin inhibited the epidermal growth factor (EGF) induced activation of matrix metalloproteinase (MMP)-9 and MMP-2 , and further inhibited cell invasion and migration ... Capsaicin decreased the EGF induced expression of MMP-9, MMP-2 , and MT1-MMP, but did not alter TIMP-1 and TIMP-2 levels
Zhang et al., Inflammation 2012 (Arthritis, Rheumatoid...) : IL-1ß or TNF-a increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes ; EGF stimulated expression of MMP-9 but not of MMP-2 ; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1ß or TNF-a ; rMMP-9, rMMP-2, or their inhibitors had no effect on the ( 3 ) H-TdR incorporation of synovial cells
Park et al., Br J Nutr 2013 (Neoplasm Invasiveness...) : Maslinic acid significantly ( P < 0·05 ) down-regulated both basal and EGF stimulated secretion of matrix metalloproteinase (MMP)-9 ( 25-67 % ), MMP-2 ( 50-86 % ), urokinase-type plasminogen activator ( uPA, about 100 % ), vascular endothelial growth factor ( VEGF, 98-100 % ) and tissue inhibitors of metalloproteinases ( TIMP ) -1, as well as expression of uPA receptor (uPAR), intercellular adhesion molecules ( 22-33 % ), vascular cell adhesion molecules ( 23-46 % ) and E-cadherin, whereas it increased TIMP-2 secretion
Ueda et al., Int J Cancer 1997 (Carcinoma, Squamous Cell...) : We investigated the effects of epidermal growth factor (EGF) and transforming growth factor (TGF)-alpha on migration, invasion and matrix metalloproteinase ( MMP ) expression of uterine cervical-carcinoma SKG-IIIb cells, and whether these growth factors affect pyrimidine-nucleoside-phosphorylase ( PyNPase ) activity and 5'-deoxy-5-fluorouridine ( 5'-dFUrd ) sensitivity of tumor cells
Piedagnel et al., J Biol Chem 1999 : Matrix metalloproteinase 2 (MMP2) and MMP9 are produced by kidney collecting duct principal cells but are differentially regulated by SV40 large-T, arginine vasopressin, and epidermal growth factor