◀ Back to CDK1
CDC25B — CDK1
Pathways - manually collected, often from reviews:
-
KEGG Cell cycle:
CDC25B/CDC25C
→
CDK1
(protein-protein, dephosphorylation)
-
KEGG Progesterone-mediated oocyte maturation:
CDC25A/CDC25B/CDC25C
→
CDK1
(protein-protein, activation)
-
NCI Pathway Database PLK1 signaling events:
CDC25B (CDC25B)
→
Cyclin B1/CDK1 complex (CCNB1-CDK1)
(modification, activates)
van Vugt et al., Mol Cell 2004*
Evidence: mutant phenotype
-
Reactome Reaction:
CDK1
→
CDC25B
(reaction)
Mailand et al., Science 2000*, Mailand et al., EMBO J 2002*, Strausfeld et al., Nature 1991*, Strausfeld et al., J Biol Chem 1994*, Honda et al., FEBS Lett 1993*
-
WikiPathways Cell Cycle:
CDC25B/CDC25C
→
CDK1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CDK1
—
CDC25B
(physical association, affinity chromatography technology)
Vincent et al., Neuroscience 2001*
-
IRef Hprd Interaction:
CDK1
—
CDC25B
(in vitro)
Baldin et al., J Biol Chem 2002*, Honda et al., FEBS Lett 1993*, Draetta et al., Biochim Biophys Acta 1997*, Booher et al., J Biol Chem 1997*, Jin et al., J Cell Biol 1998*, Hofmann et al., J Mol Biol 1998*
Text-mined interactions from Literome
Lindqvist et al., J Cell Biol 2005
:
Further, three-dimensional time-lapse microscopy and quantification of Cdk1 phosphorylation versus cyclin B1 levels in individual cells revealed that Cdc25A and -B exert specific functions in the initiation of mitosis : Cdc25A may play a role in chromatin condensation, whereas
Cdc25B specifically
activates cyclin
B1-Cdk1 on centrosomes
Wierstra et al., Biochem Biophys Res Commun 2008
:
Others reported that a cyclin/Cdk binding LXL-motif of the splice variant FoxM1b is required for its interaction with Cdk2, Cdk1, and p27, its phosphorylation by
Cdk1 and its
activation by
Cdc25B
Solc et al., Dev Biol 2008
:
Although CDC25C is not essential for either mitotic or meiotic cell cycle regulation,
CDC25B is
essential for
CDK1 activation during resumption of meiosis
Varmeh et al., J Biol Chem 2009
:
Forced expression of
Cdc25B inappropriately
up-regulated the activity of
Cdk1 and Cdk2, by reducing levels of inhibitory phosphorylation
Sullivan et al., PloS one 2012
:
Prior literature reported that
CDC25B and CDC25C
activate CDK1/cyclinB complexes in order to enable phosphorylation of FOXM1