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PXN — RAC3

Text-mined interactions from Literome

Chen et al., Mol Cell Biol 2005 : Supporting these genetic data, biochemical studies indicate that paxillin regulates Rac and Rho activity, positively regulating Rac and negatively regulating Rho
Kobayashi et al., Mol Cell Biol 2006 (Neoplasm Invasiveness...) : GSK-3 inhibitors suppressed the disassembly of paxillin and the activation of FAK and Rac
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2007 : Paxillin-beta-catenin interactions are involved in Rac/Cdc42 mediated endothelial barrier-protective response to oxidized phospholipids
Saito et al., Biol Pharm Bull 2008 (Wounds and Injuries) : TNIIIA2-treatment unaffected autophosphorylation of focal adhesion kinase ( FAK ), but induced its physical association with phospho-paxillin ( Tyr118 ), suggesting the FAK/paxillin dependent negative regulation of Rac activation
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2008 : Our results demonstrate that OxPAPC induced Rac dependent , Rho independent peripheral accumulation of paxillin containing FAs and time dependent paxillin phosphorylation
Choi et al., Circ Res 2009 (Chronic Disease...) : We show that mmLDL induced recruitment of spleen tyrosine kinase (Syk) to a TLR4 signaling complex, TLR4 phosphorylation, activation of a Vav1-Ras-Raf-MEK-ERK1/2 signaling cascade, phosphorylation of paxillin , and activation of Rac , Cdc42, and Rho
Hajdo-Milasinovic et al., J Cell Sci 2009 : Interestingly, Rac3 expression severely attenuates the interaction between GIT1 and paxillin , accompanied by defective paxillin distribution, focal adhesion formation and disturbed cell spreading
Tong et al., Biochim Biophys Acta 2013 : TG-2 dependent ß-3 integrin activation, serine-phosphorylation of paxillin , and Rac and CDC42 activation may thus play a key functional role in enhancing corneal epithelial cell adhesion and migration during wound healing