◀ Back to TP53

CARM1 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) (transcription, activates)
  An et al., Cell 2004, Gamper et al., Mol Cell Biol 2008
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Direct p53 effectors: PRMT1 (PRMT1) → p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) (modification, collaborate)
  An et al., Cell 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Direct p53 effectors: p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) → nucleus (EP300/CREBBP) (modification, collaborate) An et al., Cell 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Direct p53 effectors: p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) → CARM1 (CARM1) (modification, collaborate) An et al., Cell 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Direct p53 effectors: p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) → p53 (tetramer) complex (TP53) (modification, collaborate)
  An et al., Cell 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Direct p53 effectors: CARM1 (CARM1) → p53 (tetramer) complex (TP53) (modification, collaborate)
  An et al., Cell 2004
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CARM1 — TP53 An et al., Cell 2004
• IRef Bind Interaction: Complex of EP300-CARM1-TP53 An et al., Cell 2004
• IRef Bind_translation Interaction: CARM1 — TP53 (coimmunoprecipitation) An et al., Cell 2004
• IRef Bind_translation Interaction: CARM1 — TP53 (affinity chromatography technology) An et al., Cell 2004
• IRef Biogrid Interaction: CARM1 — TP53 (direct interaction, pull down) An et al., Cell 2004
• IRef Ophid Interaction: CARM1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kim et al., BMC cancer 2010 (Breast Neoplasms...) : Indeed, CARM1 significantly regulated both p53 and NF-kappaB target gene transcription
Fuchs-Young et al., Breast Cancer Res Treat 2011 (Cell Transformation, Neoplastic...) : Previous studies from our laboratory have shown that p53 regulates ER expression transcriptionally, by binding the ER promoter and forming a complex with CARM1 , CBP, c-Jun, RNA polymerase II and Sp1