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HMGB1 — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
HMGB1
—
TP53
Jayaraman et al., Genes Dev 1998*
-
IRef Bind_translation Interaction:
HMGB1
—
TP53
(far western blotting)
Jayaraman et al., Genes Dev 1998*
-
IRef Bind_translation Interaction:
HMGB1
—
TP53
(experimental interaction detection)
Jayaraman et al., Genes Dev 1998*
-
IRef Biogrid Interaction:
HMGB1
—
TP53
(physical association, affinity chromatography technology)
Imamura et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
HMGB1
—
TP53
(direct interaction, pull down)
Imamura et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
HMGB1
—
TP53
(direct interaction, pull down)
Dintilhac et al., J Biol Chem 2002
-
IRef Dip Interaction:
HMGB1
—
TP53
(direct interaction, experimental interaction detection)
Jayaraman et al., Genes Dev 1998*
-
IRef Dip Interaction:
HMGB1
—
TP53
(direct interaction, affinity chromatography technology)
Jayaraman et al., Genes Dev 1998*
-
IRef Dip Interaction:
HMGB1
—
TP53
(direct interaction, isothermal titration calorimetry)
Rowell et al., Structure 2012*
-
IRef Dip Interaction:
HMGB1
—
TP53
(direct interaction, nuclear magnetic resonance)
Rowell et al., Structure 2012*
-
IRef Dip Interaction:
HMGB1
—
TP53
(direct interaction, molecular sieving)
Rowell et al., Structure 2012*
-
IRef Dip Interaction:
HMGB1
—
TP53
(direct interaction, cross-linking study)
Rowell et al., Structure 2012*
-
IRef Hprd Interaction:
TP53
—
HMGB1
(in vivo)
Imamura et al., J Biol Chem 2001*, Dintilhac et al., J Biol Chem 2002, Jayaraman et al., Genes Dev 1998*
-
IRef Hprd Interaction:
TP53
—
HMGB1
(in vitro)
Imamura et al., J Biol Chem 2001*, Dintilhac et al., J Biol Chem 2002, Jayaraman et al., Genes Dev 1998*
-
IRef Intact Interaction:
HMGB1
—
TP53
(physical association, far western blotting)
Jayaraman et al., Genes Dev 1998*
-
IRef Ophid Interaction:
HMGB1
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
HMGB1
—
TP53
(aggregation, confirmational text mining)
Jayaraman et al., Genes Dev 1998*
Text-mined interactions from Literome
Imamura et al., J Biol Chem 2001
:
Cisplatin modified DNA binding by
HMG1 was significantly
enhanced by
p53 ... Interaction of
p53 with HMG1 after DNA damage may
promote activation of specific
HMG1 binding to damaged DNA in vivo and provide a molecular link between DNA damage and p53 mediated DNA repair
Yoshida et al., Cancer Res 2003
:
Interaction between mtTFA and
p53 required the
high mobility group-box1 or high mobility group-box2 of mtTFA and amino acids 363-376 of p53
Davalos et al., J Cell Biol 2013
(Inflammation) :
p53 dependent release of Alarmin
HMGB1 is a central mediator of senescent phenotypes
Jayaraman et al., Genes Dev 1998
:
High mobility group protein-1 (HMG-1) is a unique
activator of
p53 ... We demonstrate that recombinant His tagged
HMG-1 enhances
p53 DNA binding in vitro and also that HMG-1 and p53 can interact directly in vitro ... Finally, using transient transfection assays we show that
HMG-1 can
increase p53 and p53Delta30 mediated transactivation in vivo ... HMG-1 promotes the assembly of higher order p53 nucleoprotein structures, and these data, along with the fact that HMG-1 is capable of bending DNA, suggest that
HMG-1 may
activate p53 DNA binding by a novel mechanism involving a structural change in the target DNA