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MAX — TP53

Pathways - manually collected, often from reviews:

• FastForward regulation: MAX → TP53 (transcriptional regulation, decrease) Roy et al., Mol Cell Biol 1994*
  Evidence: PROMACTIVITY
• FastForward regulation: MYC, MAX → TP53 (transcriptional regulation, increase) Roy et al., Mol Cell Biol 1994*
  Evidence: PROMACTIVITY

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 88 proteins (association, tandem affinity purification) Agrawal et al., Cell cycle (Georgetown, Tex.) 2010

Text-mined interactions from Literome

Kirch et al., Oncogene 1999 : Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max
Yang et al., Hepatology 2009 (Cholestasis...) : Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes ... The current work tested the hypothesis that the switch from Mnt-Max to Myc-Max is responsible for p53 and cyclin D1 up-regulation and apoptosis during cholestasis