Gene interactions and pathways from curated databases and text-mining

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MIR34A — TP53

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MIR34A → TP53 (directlyIncreases, MIR34A Activity) Raver-Shapira et al., Mol Cell 2007*
    Evidence: p53 also modulates the levels of microRNAs (miRNAs). Specifically, p53 can induce expression of microRNA-34a (miR-34a) in cultured cells as well as in irradiated mice, by binding to a perfect p53 binding site located within the gene that gives rise to miR-34a.

Text-mined interactions from Literome

Fujita et al., Biochem Biophys Res Commun 2008 (Prostatic Neoplasms) : Tumor suppressor p53 transcriptionally regulates expression of microRNA-34a , which confers translational inhibition and mRNA degradation of genes involved in cell cycle control and apoptosis
Nalls et al., PloS one 2011 (Neoplasm Invasiveness...) : MiR-34a upregulation by these agents also induced acetylated p53 , p21 ( WAF1 ), p27 ( KIP1 ) and PUMA in pancreatic CSCs. Inhibition of miR-34a by antagomiR abrogates the effects of 5-Aza-dC and SAHA, suggesting that 5-Aza-dC and SAHA regulate stem cell characteristics through miR-34a