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CXCL12 — IL32
Text-mined interactions from Literome
Damås et al., Circulation 2002
(Angina, Unstable) :
In vitro,
SDF-1alpha ( 500 ng/mL )
reduced both unstimulated and endotoxin/mitogen stimulated mRNA and protein levels of monocyte chemoattractant protein-1,
interleukin-8 , matrix metalloproteinase-9, and tissue factor while increasing tissue inhibitor of metalloproteinases-1 in PBMC from patients with unstable angina
Heinhuis et al., Ann Rheum Dis 2011
(Arthritis, Rheumatoid) :
TNFa stimulation of FLS after silencing IL-32? resulted in diminished IL-6 and CXCL8 production, whereas
IL-32? overexpression
resulted in enhanced IL-6 and
CXCL8 levels ... Remarkably, the mechanism through which
IL-32? overexpression
induced TNFa, IL-1ß and
CXCL8 was by counteracting messenger RNA decay