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Kim et al., Exp Mol Med 2006
:
In addition, secretin induces sustained mitogen activated protein kinase ( MAPK ) activation and also stimulates the cAMP secretion
Harikumar et al., Biochemistry 2009
:
There were no observed changes in secretin stimulated cAMP, intracellular calcium, ERK1/2 phosphorylation, or receptor internalization in receptor bearing COS or CHO-K1 cells in the presence or absence of exogenous RAMP transfection, although the secretin receptor trafficks normally to the cell surface in these cells in a RAMP independent manner, resulting in both free and RAMP associated receptor on the cell surface